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Bioorganic & Medicinal Chemistry Letters|December 17, 2008
Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R: elimination of an acid-mediated decomposition pathwayStanley D Chamberlain, Anikó M Redman, Samarjit Patnaik, et al.Journal of Medicinal Chemistry|August 16, 2013
Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agentsAnna L Leivers, Matthew Tallant, J Brad Shotwell, et al.Bioorganic & Medicinal Chemistry Letters|April 28, 2009
Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinaseSamarjit Patnaik, Kirk L Stevens, Roseanne Gerding, et al.Journal of Medicinal Chemistry|February 15, 2019
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV InhibitorPek Y Chong, J Brad Shotwell, John Miller, et al.Molecular Cancer Therapeutics|October 15, 2009
GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancersPeter Sabbatini, Susan Korenchuk, Jason L Rowand, et al.Journal of Medicinal Chemistry|July 14, 2018
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315Clarissa G Jakob, Anup K Upadhyay, Pamela L Donner, et al.Bioorganic & Medicinal Chemistry Letters|December 6, 2008
Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinaseStanley D Chamberlain, Joseph W Wilson, Felix Deanda, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical CharacterizationJ Brad Shotwell, Subramanian Baskaran, Pek Chong, et al.Bioorganic & Medicinal Chemistry Letters|December 17, 2008
Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivityStanley D Chamberlain, Anikó M Redman, Joseph W Wilson, et al.The Journal of Biological Chemistry|June 10, 2015
The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral InhibitorsEdgar R Wood, Randy Bledsoe, Jing Chai, et al.Pageof 3