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Journal of Medicinal Chemistry|June 26, 2009
In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonistsRichard A Hartz, Vijay T Ahuja, Maria Rafalski, et al.Journal of Medicinal Chemistry|December 4, 2009
A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonistRichard A Hartz, Vijay T Ahuja, Xiaoliang Zhuo, et al.Bioorganic & Medicinal Chemistry Letters|February 19, 2015
Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88Carolyn D Dzierba, Yingzhi Bi, Bireshwar Dasgupta, et al.Bioorganic & Medicinal Chemistry Letters|September 27, 2012
[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agentsJeffrey A Deskus, Douglas D Dischino, Ronald J Mattson, et al.Journal of Medicinal Chemistry|February 16, 2022
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 InhibitorsRichard A Hartz, Vijay T Ahuja, Susheel J Nara, et al.ACS Medicinal Chemistry Letters|April 17, 2024
Empowering Voices: Inspiring Women in Medicinal ChemistryMaria-Jesus Blanco, Joanne J Bronson, Erin F DiMauro, et al.Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents|June 26, 2023
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of painCarolyn D Dzierba, Bireshwar Dasgupta, George Karageorge, et al.Journal of Medicinal Chemistry|March 8, 2024
Empowering Voices: Inspiring Women in Medicinal ChemistryMaria-Jesus Blanco, Joanne J Bronson, Erin F DiMauro, et al.Journal of Medicinal Chemistry|March 2, 2026
Optimization of α-Fluoro, β-Heteroaryl Acrylamide Warheads for KRASG12C Active-State InhibitionMatthew L Condakes, Rita L Civiello, Brian L Venables, et al.Journal of Medicinal Chemistry|June 26, 2009
Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonistsRichard A Hartz, Vijay T Ahuja, Argyrios G Arvanitis, et al.Pageof 12