J E Hawkinson - JoVE Visualize

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The Journal of Pharmacology and Experimental Therapeutics|September 19, 2000

Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptorsK E Vanover, S Rosenzweig-Lipson, J E Hawkinson, et al.

Journal of Medicinal Chemistry|February 28, 1997

Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptorS X Cai, S M Kher, Z L Zhou, et al.

Journal of Medicinal Chemistry|January 3, 1997

3 alpha-Hydroxy-3 beta-(phenylethynyl)-5 beta-pregnan-20-ones: synthesis and pharmacological activity of neuroactive steroids with high affinity for GABAA receptorsR B Upasani, K C Yang, M Acosta-Burruel, et al.

The Journal of Pharmacology and Experimental Therapeutics|July 1, 1997

CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the ratD M Edgar, W F Seidel, K W Gee, et al.

Journal of Medicinal Chemistry|August 16, 1996

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine siteS X Cai, Z L Zhou, J C Huang, et al.

Bioorganic & Medicinal Chemistry|August 16, 2001

Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonistsZ L Zhou, J M Navratil, S X Cai, et al.

Journal of Medicinal Chemistry|November 8, 1996

Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sitesA P Guzikowski, S X Cai, S A Espitia, et al.

Molecular Pharmacology|May 1, 1996

3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptorJ E Hawkinson, J A Drewe, C L Kimbrough, et al.

The Journal of Pharmacology and Experimental Therapeutics|October 9, 1998

Substituted 3beta-phenylethynyl derivatives of 3alpha-hydroxy-5alpha-pregnan-20-one: remarkably potent neuroactive steroid modulators of gamma-aminobutyric acidA receptorsJ E Hawkinson, M Acosta-Burruel, K C Yang, et al.

Journal of Medicinal Chemistry|January 3, 1997

Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptorD J Hogenkamp, S H Tahir, J E Hawkinson, et al.

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The Journal of Pharmacology and Experimental Therapeutics|September 19, 2000

Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptorsK E Vanover, S Rosenzweig-Lipson, J E Hawkinson, et al.

Journal of Medicinal Chemistry|February 28, 1997

Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptorS X Cai, S M Kher, Z L Zhou, et al.

Journal of Medicinal Chemistry|January 3, 1997

3 alpha-Hydroxy-3 beta-(phenylethynyl)-5 beta-pregnan-20-ones: synthesis and pharmacological activity of neuroactive steroids with high affinity for GABAA receptorsR B Upasani, K C Yang, M Acosta-Burruel, et al.

The Journal of Pharmacology and Experimental Therapeutics|July 1, 1997

CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the ratD M Edgar, W F Seidel, K W Gee, et al.

Journal of Medicinal Chemistry|August 16, 1996

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine siteS X Cai, Z L Zhou, J C Huang, et al.

Bioorganic & Medicinal Chemistry|August 16, 2001

Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonistsZ L Zhou, J M Navratil, S X Cai, et al.

Journal of Medicinal Chemistry|November 8, 1996

Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sitesA P Guzikowski, S X Cai, S A Espitia, et al.

Molecular Pharmacology|May 1, 1996

3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptorJ E Hawkinson, J A Drewe, C L Kimbrough, et al.

The Journal of Pharmacology and Experimental Therapeutics|October 9, 1998

Substituted 3beta-phenylethynyl derivatives of 3alpha-hydroxy-5alpha-pregnan-20-one: remarkably potent neuroactive steroid modulators of gamma-aminobutyric acidA receptorsJ E Hawkinson, M Acosta-Burruel, K C Yang, et al.

Journal of Medicinal Chemistry|January 3, 1997

Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptorD J Hogenkamp, S H Tahir, J E Hawkinson, et al.

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