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ACS Medicinal Chemistry Letters|October 18, 2023
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-LifeKevin J Filipski, David J Edmonds, Michelle R Garnsey, et al.Journal of Medicinal Chemistry|April 4, 2015
Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) AgonistsHuy N Hoang, Kun Song, Timothy A Hill, et al.Journal of Medicinal Chemistry|August 29, 2013
Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structureDavid A Griffith, Robert L Dow, Kim Huard, et al.ACS Medicinal Chemistry Letters|October 15, 2014
Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally AbsorbedTimothy A Hill, Rink-Jan Lohman, Huy N Hoang, et al.Journal of Medicinal Chemistry|June 1, 2022
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 ReceptorDavid A Griffith, David J Edmonds, Jean-Philippe Fortin, et al.The Journal of Pharmacology and Experimental Therapeutics|March 15, 2017
Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic NephropathyChristopher T Salatto, Russell A Miller, Kimberly O Cameron, et al.Journal of Medicinal Chemistry|August 5, 2016
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic NephropathyKimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, et al.Journal of Medicinal Chemistry|August 19, 2020
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver TargetingKim Huard, Aaron C Smith, Gregg Cappon, et al.Nature Communications|January 2, 2025
Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variantsMichelle R Garnsey, Yang Wang, David J Edmonds, et al.Journal of Medicinal Chemistry|February 22, 2018
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK)David J Edmonds, Daniel W Kung, Amit S Kalgutkar, et al.Pageof 25