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Journal of Medicinal Chemistry|August 6, 2019

Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective MethylationTim N Barrett, Jonathan A Taylor, Daniel Barker, et al.

Bioorganic & Medicinal Chemistry Letters|November 21, 2008

Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonistsHeather A Barnett, Diane M Coe, Tony W J Cooper, et al.

Drug Discovery Today|September 21, 2013

A practical drug discovery project at the undergraduate levelM Jonathan Fray, Simon J F Macdonald, Ian R Baldwin, et al.

Journal of Medicinal Chemistry|November 28, 2007

Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivityKeith Biggadike, Mohamed Boudjelal, Margaret Clackers, et al.

Journal of Medicinal Chemistry|August 23, 2002

Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)Simon J F Macdonald, Michael D Dowle, Lee A Harrison, et al.

Journal of Medicinal Chemistry|July 11, 2006

Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine seriesMike Barker, Margaret Clackers, Royston Copley, et al.

Journal of Medicinal Chemistry|September 15, 2018

Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αPanayiotis A Procopiou, Niall A Anderson, John Barrett, et al.

ACS Medicinal Chemistry Letters|November 20, 2014

Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl SubstituentsJames Adams, Edward C Anderson, Emma E Blackham, et al.

European Journal of Pharmacology|November 11, 2021

Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic diseaseAlex L Wilkinson, Alison E John, John W Barrett, et al.

Antimicrobial Agents and Chemotherapy|November 25, 2004

Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimenSimon J F Macdonald, Keith G Watson, Rachel Cameron, et al.

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Showing results (171-180 of 184) with videos related to

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Pageof 19

Journal of Medicinal Chemistry|August 6, 2019

Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective MethylationTim N Barrett, Jonathan A Taylor, Daniel Barker, et al.

Bioorganic & Medicinal Chemistry Letters|November 21, 2008

Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonistsHeather A Barnett, Diane M Coe, Tony W J Cooper, et al.

Drug Discovery Today|September 21, 2013

A practical drug discovery project at the undergraduate levelM Jonathan Fray, Simon J F Macdonald, Ian R Baldwin, et al.

Journal of Medicinal Chemistry|November 28, 2007

Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivityKeith Biggadike, Mohamed Boudjelal, Margaret Clackers, et al.

Journal of Medicinal Chemistry|August 23, 2002

Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)Simon J F Macdonald, Michael D Dowle, Lee A Harrison, et al.

Journal of Medicinal Chemistry|July 11, 2006

Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine seriesMike Barker, Margaret Clackers, Royston Copley, et al.

Journal of Medicinal Chemistry|September 15, 2018

Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αPanayiotis A Procopiou, Niall A Anderson, John Barrett, et al.

ACS Medicinal Chemistry Letters|November 20, 2014

Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl SubstituentsJames Adams, Edward C Anderson, Emma E Blackham, et al.

European Journal of Pharmacology|November 11, 2021

Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic diseaseAlex L Wilkinson, Alison E John, John W Barrett, et al.

Antimicrobial Agents and Chemotherapy|November 25, 2004

Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimenSimon J F Macdonald, Keith G Watson, Rachel Cameron, et al.

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