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Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 11, 2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modificationDaniel J Warner, Hongming Chen, Louis-David Cantin, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|August 2, 2012
Characterization of THLE-cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activityYalda Soltanpour, Constanze Hilgendorf, Marie M Ahlström, et al.Integrative Biology : Quantitative Biosciences From Nano to Macro|May 2, 2013
Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and ratsSuzanne Geenen, James W T Yates, J Gerry Kenna, et al.Toxicology Research|August 10, 2018
Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acidJames A Akingbasote, Alison J Foster, Huw B Jones, et al.Journal of Pharmaceutical and Biomedical Analysis|July 15, 2011
HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture mediumSuzanne Geenen, Cristina Guallar-Hoyas, Filippos Michopoulos, et al.Chemical Research in Toxicology|December 14, 2012
Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metaboliteAlison J Foster, Lucy H Prime, Frida Gustafsson, et al.NMR in Biomedicine|April 9, 2013
Assessment of gadoxetate DCE-MRI as a biomarker of hepatobiliary transporter inhibitionJose L Ulloa, Simone Stahl, James Yates, et al.Toxicology in Vitro : an International Journal Published in Association with BIBRA|November 6, 2013
Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytesHelen Garside, Karen F Marcoe, Jessica Chesnut-Speelman, et al.Xenobiotica; the Fate of Foreign Compounds in Biological Systems|December 29, 2011
Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized liversTimothy Schulz-Utermoehl, Sunil Sarda, John R Foster, et al.Drug Discovery Today. Technologies|October 15, 2015
Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolismSimone H Stahl, James W Yates, Andrew W Nicholls, et al.Pageof 4