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Chemico-Biological Interactions|November 16, 2010
Risk assessment and mitigation strategies for reactive metabolites in drug discovery and developmentRichard A Thompson, Emre M Isin, Yan Li, et al.
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences|September 6, 2011
A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolismSuzanne Geenen, Franco B du Preez, Michael Reed, et al.
Biochimica Et Biophysica Acta|May 7, 2013
Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategySuzanne Geenen, Franco B du Preez, Jacky L Snoep, et al.
Toxicology and Applied Pharmacology|October 22, 2024
In vitro pharmacologic profiling aids systemic toxicity assessment of chemicalsMatthew Burbank, Predrag Kukic, Gladys Ouedraogo, et al.
Archives of Toxicology|April 24, 2013
In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acidAlison V M Rodrigues, Helen E Rollison, Scott Martin, et al.
Magma (New York, N.Y.)|August 6, 2024
Assessment of hepatic transporter function in rats using dynamic gadoxetate-enhanced MRI: a reproducibility studyEbony R Gunwhy, Catherine D G Hines, Claudia Green, et al.
The Journal of Pharmacology and Experimental Therapeutics|December 4, 2014
Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonistsJ Gerry Kenna, Simone H Stahl, Julie A Eakins, et al.
Toxicology and Applied Pharmacology|June 16, 2009
Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosisAmy E Mercer, Sophie L Regan, Charlotte M Hirst, et al.
Chemical Research in Toxicology|June 1, 2012
In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugsRichard A Thompson, Emre M Isin, Yan Li, et al.
Pharmaceutics|March 29, 2023
Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in RatsNicola Melillo, Daniel Scotcher, J Gerry Kenna, et al.
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