Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Filters

J H Freisheim

Showing results (41-50 of 88) with videos related to

Pageof 9
Sort By:
Journal of Medicinal Chemistry|May 1, 1992
Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluationA Rosowsky, R A Forsch, V E Reich, et al.
Journal of Medicinal Chemistry|May 1, 1984
Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activityA Rosowsky, R A Forsch, J H Freisheim, et al.
Anti-Cancer Drug Design|December 1, 1992
Crystal structure determination at 2.3 A of recombinant human dihydrofolate reductase ternary complex with NADPH and methotrexate-gamma-tetrazoleV Cody, J R Luft, E Ciszak, et al.
Biochemistry|June 28, 1988
Ligand-induced structural constraints in human dihydrofolate reductase revealed by peptide-specific antibodiesM Ratnam, X H Tan, N J Prendergast, et al.
Journal of Medicinal Chemistry|April 1, 1988
Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studiesA Rosowsky, H Bader, R A Forsch, et al.
Molecular Pharmacology|January 1, 1985
Regiospecific gamma-conjugation of methotrexate to poly(L-lysine). Chemical and biological studiesA Rosowsky, R A Forsch, J Galivan, et al.
Journal of Medicinal Chemistry|July 1, 1988
Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibitionA Rosowsky, R A Forsch, R G Moran, et al.
Advances in Enzyme Regulation|January 1, 1988
Photoaffinity analogues of methotrexate as folate antagonist binding probesJ H Freisheim, M Ratnam, P L Smith, et al.
The Journal of Biological Chemistry|May 15, 1990
Mapping the antigenic epitopes of human dihydrofolate reductase by systematic synthesis of peptides on solid supportsX H Tan, M Ratnam, S M Huang, et al.
Journal of Medicinal Chemistry|December 1, 1983
Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activityA Rosowsky, R Forsch, J Uren, et al.
Pageof 9

Showing results (41-50 of 88) with videos related to

Sort By:
Pageof 9
Journal of Medicinal Chemistry|May 1, 1992
Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluationA Rosowsky, R A Forsch, V E Reich, et al.
Journal of Medicinal Chemistry|May 1, 1984
Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activityA Rosowsky, R A Forsch, J H Freisheim, et al.
Anti-Cancer Drug Design|December 1, 1992
Crystal structure determination at 2.3 A of recombinant human dihydrofolate reductase ternary complex with NADPH and methotrexate-gamma-tetrazoleV Cody, J R Luft, E Ciszak, et al.
Biochemistry|June 28, 1988
Ligand-induced structural constraints in human dihydrofolate reductase revealed by peptide-specific antibodiesM Ratnam, X H Tan, N J Prendergast, et al.
Journal of Medicinal Chemistry|April 1, 1988
Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studiesA Rosowsky, H Bader, R A Forsch, et al.
Molecular Pharmacology|January 1, 1985
Regiospecific gamma-conjugation of methotrexate to poly(L-lysine). Chemical and biological studiesA Rosowsky, R A Forsch, J Galivan, et al.
Journal of Medicinal Chemistry|July 1, 1988
Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibitionA Rosowsky, R A Forsch, R G Moran, et al.
Advances in Enzyme Regulation|January 1, 1988
Photoaffinity analogues of methotrexate as folate antagonist binding probesJ H Freisheim, M Ratnam, P L Smith, et al.
The Journal of Biological Chemistry|May 15, 1990
Mapping the antigenic epitopes of human dihydrofolate reductase by systematic synthesis of peptides on solid supportsX H Tan, M Ratnam, S M Huang, et al.
Journal of Medicinal Chemistry|December 1, 1983
Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activityA Rosowsky, R Forsch, J Uren, et al.
Pageof 9