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Journal of Medicinal Chemistry
|
July 1, 1989
Inhibition of mammalian folylpolyglutamate synthetase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin bearing a terminal L-ornithine
S A Patil, B Shane, J H Freisheim, et al.
Journal of Medicinal Chemistry
|
July 1, 1988
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity
A Rosowsky, H Bader, C A Cucchi, et al.
The Journal of Biological Chemistry
|
June 5, 1989
Hydride transfer by dihydrofolate reductase. Causes and consequences of the wide range of rates exhibited by bacterial and vertebrate enzymes
W A Beard, J R Appleman, T J Delcamp, et al.
The Journal of Biological Chemistry
|
May 15, 1990
The importance of loop region residues 40-46 in human dihydrofolate reductase as revealed by site-directed mutagenesis
X H Tan, S M Huang, M Ratnam, et al.
Analytical Biochemistry
|
January 1, 1983
High-performance liquid chromatography of methotrexate analogs containing terminal lysine or ornithine and their dansyl derivatives
A A Kumar, R J Kempton, G M Anstead, et al.
Journal of Medicinal Chemistry
|
September 1, 1986
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate
A Rosowsky, H Bader, M Radike-Smith, et al.
NCI Monographs : a Publication of the National Cancer Institute
|
January 1, 1987
Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase
A Rosowsky, R G Moran, J H Freisheim, et al.
Journal of Medicinal Chemistry
|
April 1, 1989
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts
J B Hynes, S A Patil, R L Hagan, et al.
Biochemistry
|
May 30, 1989
Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase
N J Prendergast, J R Appleman, T J Delcamp, et al.
Journal of Medicinal Chemistry
|
October 1, 1986
Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition
A Rosowsky, R A Forsch, J H Freisheim, et al.
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Search research articles
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Showing results (51-60 of 88) with videos related to
Sort By:
Page
of 9
Journal of Medicinal Chemistry
|
July 1, 1989
Inhibition of mammalian folylpolyglutamate synthetase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin bearing a terminal L-ornithine
S A Patil, B Shane, J H Freisheim, et al.
Journal of Medicinal Chemistry
|
July 1, 1988
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity
A Rosowsky, H Bader, C A Cucchi, et al.
The Journal of Biological Chemistry
|
June 5, 1989
Hydride transfer by dihydrofolate reductase. Causes and consequences of the wide range of rates exhibited by bacterial and vertebrate enzymes
W A Beard, J R Appleman, T J Delcamp, et al.
The Journal of Biological Chemistry
|
May 15, 1990
The importance of loop region residues 40-46 in human dihydrofolate reductase as revealed by site-directed mutagenesis
X H Tan, S M Huang, M Ratnam, et al.
Analytical Biochemistry
|
January 1, 1983
High-performance liquid chromatography of methotrexate analogs containing terminal lysine or ornithine and their dansyl derivatives
A A Kumar, R J Kempton, G M Anstead, et al.
Journal of Medicinal Chemistry
|
September 1, 1986
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate
A Rosowsky, H Bader, M Radike-Smith, et al.
NCI Monographs : a Publication of the National Cancer Institute
|
January 1, 1987
Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase
A Rosowsky, R G Moran, J H Freisheim, et al.
Journal of Medicinal Chemistry
|
April 1, 1989
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts
J B Hynes, S A Patil, R L Hagan, et al.
Biochemistry
|
May 30, 1989
Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase
N J Prendergast, J R Appleman, T J Delcamp, et al.
Journal of Medicinal Chemistry
|
October 1, 1986
Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition
A Rosowsky, R A Forsch, J H Freisheim, et al.
Page
of 9