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J H Freisheim

Showing results (71-80 of 88) with videos related to

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Journal of Medicinal Chemistry|May 1, 1985
Methotrexate analogues. 25. Chemical and biological studies on the gamma-tert-butyl esters of methotrexate and aminopterinA Rosowsky, J H Freisheim, H Bader, et al.
Biochemistry|February 5, 1991
Role of the conserved active site residue tryptophan-24 of human dihydrofolate reductase as revealed by mutagenesisW A Beard, J R Appleman, S M Huang, et al.
The Journal of Biological Chemistry|February 15, 1989
Atypical transient state kinetics of recombinant human dihydrofolate reductase produced by hysteretic behavior. Comparison with dihydrofolate reductases from other sourcesJ R Appleman, W A Beard, T J Delcamp, et al.
The Journal of Rheumatology|August 1, 1988
Methotrexate suppresses passive adjuvant arthritis: studies on the metabolism of methotrexate in mononuclear cells derived from normal and adjuvant arthritic ratsS C Ridge, K M Ferguson, N Rath, et al.
Journal of Medicinal Chemistry|October 15, 1993
2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductaseA Rosowsky, C E Mota, J E Wright, et al.
Biochemical Pharmacology|March 1, 1991
Studies on the mechanism of antitumor action of 2-desamino-2-methyl-5,8-dideazaisofolic acidR L Hagan, D S Duch, G K Smith, et al.
Journal of Medicinal Chemistry|May 1, 1986
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chainA Rosowsky, J H Freisheim, R G Moran, et al.
Biochemical Pharmacology|October 1, 1986
Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chainA Rosowsky, R C Moran, R A Forsch, et al.
Journal of Medicinal Chemistry|February 1, 1991
Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analoguesS K Singh, I K Dev, D S Duch, et al.
Advances in Enzyme Regulation|January 1, 1992
Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell linesJ H Freisheim, M Ratnam, T P McAlinden, et al.
Pageof 9

Showing results (71-80 of 88) with videos related to

Sort By:
Pageof 9
Journal of Medicinal Chemistry|May 1, 1985
Methotrexate analogues. 25. Chemical and biological studies on the gamma-tert-butyl esters of methotrexate and aminopterinA Rosowsky, J H Freisheim, H Bader, et al.
Biochemistry|February 5, 1991
Role of the conserved active site residue tryptophan-24 of human dihydrofolate reductase as revealed by mutagenesisW A Beard, J R Appleman, S M Huang, et al.
The Journal of Biological Chemistry|February 15, 1989
Atypical transient state kinetics of recombinant human dihydrofolate reductase produced by hysteretic behavior. Comparison with dihydrofolate reductases from other sourcesJ R Appleman, W A Beard, T J Delcamp, et al.
The Journal of Rheumatology|August 1, 1988
Methotrexate suppresses passive adjuvant arthritis: studies on the metabolism of methotrexate in mononuclear cells derived from normal and adjuvant arthritic ratsS C Ridge, K M Ferguson, N Rath, et al.
Journal of Medicinal Chemistry|October 15, 1993
2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductaseA Rosowsky, C E Mota, J E Wright, et al.
Biochemical Pharmacology|March 1, 1991
Studies on the mechanism of antitumor action of 2-desamino-2-methyl-5,8-dideazaisofolic acidR L Hagan, D S Duch, G K Smith, et al.
Journal of Medicinal Chemistry|May 1, 1986
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chainA Rosowsky, J H Freisheim, R G Moran, et al.
Biochemical Pharmacology|October 1, 1986
Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chainA Rosowsky, R C Moran, R A Forsch, et al.
Journal of Medicinal Chemistry|February 1, 1991
Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analoguesS K Singh, I K Dev, D S Duch, et al.
Advances in Enzyme Regulation|January 1, 1992
Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell linesJ H Freisheim, M Ratnam, T P McAlinden, et al.
Pageof 9