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The Journal of Biological Chemistry|January 27, 1995
A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticineS H Elsea, Y Hsiung, J L Nitiss, et al.
The Journal of Biological Chemistry|September 1, 1995
A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitorsY Hsiung, S H Elsea, N Osheroff, et al.
The Journal of Biological Chemistry|May 17, 2001
Overexpression of type I topoisomerases sensitizes yeast cells to DNA damageJ L Nitiss, K C Nitiss, A Rose, et al.
Cancer Research|June 1, 1994
Yeast topoisomerase II mutants resistant to anti-topoisomerase agents: identification and characterization of new yeast topoisomerase II mutants selected for resistance to etoposideY X Liu, Y Hsiung, M Jannatipour, et al.
The Journal of Biological Chemistry|September 25, 1999
Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactionsD Strumberg, J L Nitiss, J Dong, et al.
The Journal of Biological Chemistry|March 6, 1999
Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactionsD Strumberg, J L Nitiss, A Rose, et al.
Cancer Research|January 1, 1996
Functional expression of human topoisomerase II alpha in yeast: mutations at amino acids 450 or 803 of topoisomerase II alpha result in enzymes that can confer resistance to anti-topoisomerase II agentsY Hsiung, M Jannatipour, A Rose, et al.
The Journal of Biological Chemistry|October 24, 1998
A mutant yeast topoisomerase II (top2G437S) with differential sensitivity to anticancer drugs in the presence and absence of ATPM Sabourin, J A Byl, S E Hannah, et al.
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology|October 29, 2000
Thioguanine substitution alters DNA cleavage mediated by topoisomerase IIN F Krynetskaia, X Cai, J L Nitiss, et al.
Biochemistry|April 16, 1998
The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase IIJ L Nitiss, J Zhou, A Rose, et al.
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