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Cancer Research|August 15, 1992
Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase IIJ L Nitiss, Y X Liu, P Harbury, et al.
FEBS Letters|October 18, 2000
N-terminal and core-domain random mutations in human topoisomerase II alpha conferring bisdioxopiperazine resistanceL H Jensen, I Wessel, M Møller, et al.
Journal of Agricultural and Food Chemistry|November 24, 1999
Biologically active carbazole alkaloids from Murraya koenigiiR S Ramsewak, M G Nair, G M Strasburg, et al.
Cancer Research|June 1, 1995
DNA topoisomerase II is the molecular target of bisdioxopiperazine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiaeR Ishida, M Hamatake, R A Wasserman, et al.
Cancer Research|February 24, 2001
Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanineP Pourquier, J L Waltman, Y Urasaki, et al.
Biochemistry|November 26, 1999
DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancementJ A Byl, J M Fortune, D A Burden, et al.
Biochemistry|August 18, 1999
Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivityY Mao, C Yu, T S Hsieh, et al.
Cancer Research|July 23, 1999
Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoformI Wessel, L H Jensen, P B Jensen, et al.
Anti-Cancer Drug Design|October 12, 2002
Linker length in podophyllotoxin-acridine conjugates determines potency in vivo and in vitro as well as specificity against MDR cell linesL Rothenborg-Jensen, H F Hansen, I Wessel, et al.
Cancer Research|April 16, 1998
Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazinesM Sehested, I Wessel, L H Jensen, et al.
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