Showing results (1-10 of 17) with videos related to
Sort By:
Pageof 2
Clinical Therapeutics|July 30, 2018
Safety, Tolerability, and Pharmacokinetics of Single and Repeat Doses of Nemiralisib Administered via the Ellipta Dry Powder Inhaler to Healthy SubjectsRobert Wilson, Emily Jarvis, Mickael Montembault, et al.Journal of Medicinal Chemistry|December 12, 2018
Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth ApproachNick Barton, Máire Convery, Anthony W J Cooper, et al.The Journal of Pharmacology and Experimental Therapeutics|September 16, 2018
A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled AsthmaSanjeev Khindri, Anthony Cahn, Malcolm Begg, et al.International Journal of Chronic Obstructive Pulmonary Disease|June 11, 2021
An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized TrialAnthony Cahn, J Nicole Hamblin, Jon Robertson, et al.Nature Communications|August 11, 2018
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent mannerAnne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, et al.The Journal of Pharmacology and Experimental Therapeutics|April 4, 2019
Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase <i>δ</i> InhibitorMalcolm Begg, Chris D Edwards, J Nicole Hamblin, et al.Bioorganic & Medicinal Chemistry Letters|June 10, 2008
Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitorsJ Nicole Hamblin, Tony D R Angell, Stuart P Ballantine, et al.Journal of Medicinal Chemistry|March 7, 2007
Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamidesChuen Chan, Alan D Borthwick, David Brown, et al.Bioorganic & Medicinal Chemistry Letters|August 25, 2010
Pyrazolopyridines as potent PDE4B inhibitors: 5-heterocycle SARCharlotte J Mitchell, Stuart P Ballantine, Diane M Coe, et al.International Journal of Chronic Obstructive Pulmonary Disease|June 11, 2021
Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled TrialsMalcolm Begg, J Nicole Hamblin, Emily Jarvis, et al.Pageof 2