Showing results (71-80 of 91) with videos related to

Sort By:
Pageof 10
Journal of Medicinal Chemistry|September 21, 2013
Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254)Mark Turlington, Meredith J Noetzel, Aspen Chun, et al.
Bioorganic & Medicinal Chemistry Letters|August 1, 2016
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in dispositionMichael R Wood, Meredith J Noetzel, James C Tarr, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|June 26, 2015
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse ModelA Ghoshal, J M Rook, J W Dickerson, et al.
Biological Psychiatry|November 13, 2012
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activityJerri M Rook, Meredith J Noetzel, Wendy A Pouliot, et al.
Bioorganic & Medicinal Chemistry Letters|May 20, 2017
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amidesJames C Tarr, Michael R Wood, Meredith J Noetzel, et al.
Bioorganic & Medicinal Chemistry Letters|November 2, 2017
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amidesJames C Tarr, Michael R Wood, Meredith J Noetzel, et al.
Bioorganic & Medicinal Chemistry Letters|February 17, 2015
Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)María Luz Martín-Martín, José Manuel Bartolomé-Nebreda, Susana Conde-Ceide, et al.
Bioorganic & Medicinal Chemistry Letters|December 13, 2016
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogsMichael R Wood, Meredith J Noetzel, Michael S Poslusney, et al.
Bioorganic & Medicinal Chemistry Letters|April 27, 2017
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacologyBruce J Melancon, Michael R Wood, Meredith J Noetzel, et al.
ACS Chemical Neuroscience|August 20, 2014
Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodentsMichael Bubser, Thomas M Bridges, Ditte Dencker, et al.
Pageof 10