J P Vacca - JoVE Visualize

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Journal of Medicinal Chemistry|March 1, 1988

Structure-affinity relationships of arylquinolizines at alpha-adrenoceptorsJ R Huff, J J Baldwin, S J deSolms, et al.

Journal of Medicinal Chemistry|January 20, 1995

A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active siteM K Holloway, J M Wai, T A Halgren, et al.

Bioorganic & Medicinal Chemistry Letters|January 5, 1999

Identification and SAR for a selective, nonpeptidyl thrombin inhibitorA M Naylor-Olsen, G S Ponticello, S D Lewis, et al.

Bioorganic & Medicinal Chemistry Letters|June 8, 2000

Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitorsC A Coburn, D M Rush, P D Williams, et al.

Journal of Medicinal Chemistry|May 23, 1997

Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacyT J Tucker, W C Lumma, S D Lewis, et al.

The Journal of Pharmacology and Experimental Therapeutics|March 23, 1999

Antithrombotic efficacy of thrombin inhibitor L-374,087: intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosisJ J Cook, S J Gardell, M A Holahan, et al.

Journal of Medicinal Chemistry|November 14, 1997

Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 positionT J Tucker, W C Lumma, S D Lewis, et al.

Bioorganic & Medicinal Chemistry Letters|January 5, 1999

C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorptionR C Isaacs, K J Cutrona, C L Newton, et al.

Bioorganic & Medicinal Chemistry Letters|January 1, 1999

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitorP E Sanderson, K J Cutrona, B D Dorsey, et al.

Journal of Medicinal Chemistry|November 26, 1997

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 positionD M Feng, S J Gardell, S D Lewis, et al.

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Showing results (11-20 of 25) with videos related to

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Pageof 3

Journal of Medicinal Chemistry|March 1, 1988

Structure-affinity relationships of arylquinolizines at alpha-adrenoceptorsJ R Huff, J J Baldwin, S J deSolms, et al.

Journal of Medicinal Chemistry|January 20, 1995

A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active siteM K Holloway, J M Wai, T A Halgren, et al.

Bioorganic & Medicinal Chemistry Letters|January 5, 1999

Identification and SAR for a selective, nonpeptidyl thrombin inhibitorA M Naylor-Olsen, G S Ponticello, S D Lewis, et al.

Bioorganic & Medicinal Chemistry Letters|June 8, 2000

Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitorsC A Coburn, D M Rush, P D Williams, et al.

Journal of Medicinal Chemistry|May 23, 1997

Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacyT J Tucker, W C Lumma, S D Lewis, et al.

The Journal of Pharmacology and Experimental Therapeutics|March 23, 1999

Antithrombotic efficacy of thrombin inhibitor L-374,087: intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosisJ J Cook, S J Gardell, M A Holahan, et al.

Journal of Medicinal Chemistry|November 14, 1997

Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 positionT J Tucker, W C Lumma, S D Lewis, et al.

Bioorganic & Medicinal Chemistry Letters|January 5, 1999

C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorptionR C Isaacs, K J Cutrona, C L Newton, et al.

Bioorganic & Medicinal Chemistry Letters|January 1, 1999

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitorP E Sanderson, K J Cutrona, B D Dorsey, et al.

Journal of Medicinal Chemistry|November 26, 1997

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 positionD M Feng, S J Gardell, S D Lewis, et al.

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