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Assay and Drug Development Technologies|March 21, 2012
An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kineticsAndrew M Swensen, Wende Niforatos, Timothy A Vortherms, et al.Bioorganic & Medicinal Chemistry Letters|May 25, 2005
Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitorsRichard J Perner, Chih-Hung Lee, Meiqun Jiang, et al.Journal of Medicinal Chemistry|November 14, 2003
5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinaseRichard J Perner, Yu-Gui Gu, Chih-Hung Lee, et al.Bioorganic & Medicinal Chemistry|June 24, 2010
Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonistsRichard J Perner, John R Koenig, Stanley Didomenico, et al.Bioorganic & Medicinal Chemistry Letters|May 12, 2010
Discovery of TRPV1 antagonist ABT-116Brian S Brown, Ryan Keddy, Richard J Perner, et al.Bioorganic & Medicinal Chemistry Letters|May 18, 2007
Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain modelArthur Gomtsyan, Erol K Bayburt, Ryan Keddy, et al.Pain|July 13, 2010
A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain modelPamela S Puttfarcken, Ping Han, Shailen K Joshi, et al.Bioorganic & Medicinal Chemistry Letters|August 28, 2003
Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivityGuo Zhu Zheng, Yue Mao, Chih-Hung Lee, et al.Journal of Medicinal Chemistry|June 23, 2007
In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonistsRichard J Perner, Stanley DiDomenico, John R Koenig, et al.Bioorganic & Medicinal Chemistry Letters|August 22, 2001
Pyridopyrimidine analogues as novel adenosine kinase inhibitorsG Z Zheng, C Lee, J K Pratt, et al.Pageof 4