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ACS Medicinal Chemistry Letters|April 16, 2021
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool CompoundsBrandon A Vara, Samuel M Levi, Abdelghani Achab, et al.
Nature Communications|December 8, 2015
Identification of an allosteric binding site for RORγt inhibitionMarcel Scheepstra, Seppe Leysen, Geert C van Almen, et al.
ACS Medicinal Chemistry Letters|August 25, 2020
Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) InhibitorsQinglin Pu, Hongjun Zhang, Liangqin Guo, et al.
ACS Medicinal Chemistry Letters|November 19, 2021
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase InhibitorsDerun Li, Hongjun Zhang, Thomas W Lyons, et al.
ACS Medicinal Chemistry Letters|September 16, 2021
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-OncologyMin Lu, Hongjun Zhang, Derun Li, et al.
ACS Medicinal Chemistry Letters|April 16, 2020
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer ImmunotherapyMatthew J Mitcheltree, Derun Li, Abdelghani Achab, et al.
Communications Biology|July 30, 2021
Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of actionRachel L Palte, Veronica Juan, Yacob Gomez-Llorente, et al.
ACS Medicinal Chemistry Letters|February 20, 2020
Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune DiseasesHongjun Zhang, Blair T Lapointe, Neville Anthony, et al.
SLAS Discovery : Advancing Life Sciences R & D|August 27, 2020
Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 InhibitorsBrian M Lacey, Zangwei Xu, Xiaomei Chai, et al.
ACS Medicinal Chemistry Letters|November 22, 2019
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer ImmunotherapyHongjun Zhang, Kun Liu, Qinglin Pu, et al.
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