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The Journal of Biological Chemistry|February 12, 2010
Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residuesVeli-Pekka Jaakola, J Robert Lane, Judy Y Lin, et al.Journal of Medicinal Chemistry|June 12, 2018
Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-(( trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D2 ReceptorAnitha Kopinathan, Christopher Draper-Joyce, Monika Szabo, et al.Journal of Medicinal Chemistry|December 31, 2025
Design, Synthesis, and Characterization of Novel, Subtype-Selective Fluorescent Antagonists Targeting the Nociceptin/Orphanin FQ Opioid Peptide ReceptorGeorge J Farmer, Julie Sanchez, Annabell Millns, et al.Nature Communications|October 4, 2017
Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptorsDavid A Sykes, Holly Moore, Lisa Stott, et al.Molecular Pharmacology|September 12, 2013
Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptorsJ Robert Lane, Pavel Chubukov, Wei Liu, et al.Neuropharmacology|March 9, 2026
Differential inhibition of the diverse behavioural effects of mu-opioid receptor agonists by progressive receptor depletionLauren Brown, Cory Langreck, Frances Hough, et al.Journal of Medicinal Chemistry|June 9, 2015
Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptorJeremy Shonberg, Christopher Draper-Joyce, Shailesh N Mistry, et al.Molecular Pharmacology|June 27, 2013
Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M₁ muscarinic acetylcholine receptorPeter Keov, Celine Valant, Shane M Devine, et al.Molecular Pharmacology|December 23, 2011
A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A(2a) receptorJ Robert Lane, Carmen Klein Herenbrink, Gerard J P van Westen, et al.ACS Chemical Neuroscience|February 12, 2024
In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein SignalingMeng-Hua M Tsai, Li Chen, Michael H Baumann, et al.Pageof 10