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Journal of Medicinal Chemistry|July 19, 2023
Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer AnalgesicsAlessandro Bonifazi, Elizabeth Saab, Julie Sanchez, et al.
British Journal of Pharmacology|July 25, 2023
Assessment of the potential of novel and classical opioids to induce respiratory depression in miceRob Hill, Julie Sanchez, Laura Lemel, et al.
Science (New York, N.Y.)|October 4, 2008
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonistVeli-Pekka Jaakola, Mark T Griffith, Michael A Hanson, et al.
Journal of Medicinal Chemistry|August 11, 2015
Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic LigandShailesh N Mistry, Jeremy Shonberg, Christopher J Draper-Joyce, et al.
ACS Chemical Neuroscience|September 24, 2020
Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D3 Dopamine ReceptorAmy E Moritz, Alessandro Bonifazi, Adrian M Guerrero, et al.
Molecular Psychiatry|August 19, 2018
Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivationPrashant Donthamsetti, Eduardo F Gallo, David C Buck, et al.
Biological Psychiatry|July 9, 2025
Mu Opioid Receptor Activation is Required for NMDA Receptor Antagonist Effects on Stress-induced Maladaptive BehaviorCory B Langreck, Briana Chen, Victor M Luna, et al.
Elife|January 28, 2020
Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonismJ Robert Lane, Ara M Abramyan, Pramisha Adhikari, et al.
Communications Biology|March 24, 2022
OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including GαzAlastair C Keen, Maria Hauge Pedersen, Laura Lemel, et al.
Journal of Medicinal Chemistry|February 11, 2017
Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R)Vivek Kumar, Amy E Moritz, Thomas M Keck, et al.
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