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Journal of Medicinal Chemistry
|
June 18, 2024
Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M<sub>4</sub> Muscarinic Acetylcholine Receptor
Christopher R Butler, Michael Popiolek, Laura A McAllister, et al.
Scientific Data
|
May 19, 2026
Multimodal ultra-high-field MRI, clinical, cognitive, and genetic profiles across the ALS-FTD spectrum
Thomas B Shaw, Aiman Al Najjar, Markus Barth, et al.
British Journal of Pharmacology
|
November 16, 2021
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1<sup>G93A</sup> mice
Silvia Scaricamazza, Illari Salvatori, Susanna Amadio, et al.
Acta Neuropathologica Communications
|
April 26, 2022
Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
Qiao Ding, Kaamini Kesavan, Kah Meng Lee, et al.
Journal of Medicinal Chemistry
|
May 15, 2009
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors
Allen J Duplantier, Stacey L Becker, Michael J Bohanon, et al.
Genome Medicine
|
October 16, 2025
Epigenetic profiles of tissue informative CpGs inform ALS disease status and progression
Christa Caggiano, Marco Morselli, Xiaoyu Qian, et al.
Nature Communications
|
May 29, 2024
Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis
Haressh Sajiir, Sahar Keshvari, Kuan Yau Wong, et al.
Medchemcomm
|
August 16, 2018
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy
Martin Pettersson, Douglas S Johnson, Danica A Rankic, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 4, 2015
Design and optimization of selective azaindole amide M1 positive allosteric modulators
Jennifer E Davoren, Steven V O'Neil, Dennis P Anderson, et al.
Bioorganic & Medicinal Chemistry Letters
|
June 9, 2012
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor
Daniel W Kung, Steven B Coffey, Ryan M Jones, et al.
Page
of 17
Search research articles
Search
Showing results (141-150 of 168) with videos related to
Sort By:
Page
of 17
Journal of Medicinal Chemistry
|
June 18, 2024
Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M<sub>4</sub> Muscarinic Acetylcholine Receptor
Christopher R Butler, Michael Popiolek, Laura A McAllister, et al.
Scientific Data
|
May 19, 2026
Multimodal ultra-high-field MRI, clinical, cognitive, and genetic profiles across the ALS-FTD spectrum
Thomas B Shaw, Aiman Al Najjar, Markus Barth, et al.
British Journal of Pharmacology
|
November 16, 2021
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1<sup>G93A</sup> mice
Silvia Scaricamazza, Illari Salvatori, Susanna Amadio, et al.
Acta Neuropathologica Communications
|
April 26, 2022
Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
Qiao Ding, Kaamini Kesavan, Kah Meng Lee, et al.
Journal of Medicinal Chemistry
|
May 15, 2009
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors
Allen J Duplantier, Stacey L Becker, Michael J Bohanon, et al.
Genome Medicine
|
October 16, 2025
Epigenetic profiles of tissue informative CpGs inform ALS disease status and progression
Christa Caggiano, Marco Morselli, Xiaoyu Qian, et al.
Nature Communications
|
May 29, 2024
Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis
Haressh Sajiir, Sahar Keshvari, Kuan Yau Wong, et al.
Medchemcomm
|
August 16, 2018
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy
Martin Pettersson, Douglas S Johnson, Danica A Rankic, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 4, 2015
Design and optimization of selective azaindole amide M1 positive allosteric modulators
Jennifer E Davoren, Steven V O'Neil, Dennis P Anderson, et al.
Bioorganic & Medicinal Chemistry Letters
|
June 9, 2012
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor
Daniel W Kung, Steven B Coffey, Ryan M Jones, et al.
Page
of 17