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Journal of Medicinal Chemistry
|
January 9, 2014
Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system
Allen A Thomas, Kevin W Hunt, Matthew Volgraf, et al.
The Journal of Clinical Investigation
|
March 31, 2018
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation
Fan Liao, Aimin Li, Monica Xiong, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
April 17, 2009
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Fan Zhang, Zhongshu Tang, Xu Hou, et al.
Neuron
|
January 7, 2020
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
Alicia A Nugent, Karin Lin, Bettina van Lengerich, et al.
Science Translational Medicine
|
February 6, 2015
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
Reina N Fuji, Michael Flagella, Miriam Baca, et al.
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|
August 16, 2025
Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model
Vanessa O Torres, Michelle E Pizzo, Darren Chan, et al.
Science Translational Medicine
|
May 29, 2020
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Mihalis S Kariolis, Robert C Wells, Jennifer A Getz, et al.
The Journal of Experimental Medicine
|
February 28, 2022
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme
Annie Arguello, Cathal S Mahon, Meredith E K Calvert, et al.
Cell Reports
|
July 24, 2025
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules
Robert C Wells, Padma Akkapeddi, Darren Chan, et al.
Science Translational Medicine
|
May 29, 2020
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
Julie C Ullman, Annie Arguello, Jennifer A Getz, et al.
Page
of 93
Search research articles
Search
Showing results (911-920 of 928) with videos related to
Sort By:
Page
of 93
Journal of Medicinal Chemistry
|
January 9, 2014
Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system
Allen A Thomas, Kevin W Hunt, Matthew Volgraf, et al.
The Journal of Clinical Investigation
|
March 31, 2018
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation
Fan Liao, Aimin Li, Monica Xiong, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
April 17, 2009
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Fan Zhang, Zhongshu Tang, Xu Hou, et al.
Neuron
|
January 7, 2020
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
Alicia A Nugent, Karin Lin, Bettina van Lengerich, et al.
Science Translational Medicine
|
February 6, 2015
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
Reina N Fuji, Michael Flagella, Miriam Baca, et al.
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|
August 16, 2025
Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model
Vanessa O Torres, Michelle E Pizzo, Darren Chan, et al.
Science Translational Medicine
|
May 29, 2020
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Mihalis S Kariolis, Robert C Wells, Jennifer A Getz, et al.
The Journal of Experimental Medicine
|
February 28, 2022
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme
Annie Arguello, Cathal S Mahon, Meredith E K Calvert, et al.
Cell Reports
|
July 24, 2025
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules
Robert C Wells, Padma Akkapeddi, Darren Chan, et al.
Science Translational Medicine
|
May 29, 2020
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
Julie C Ullman, Annie Arguello, Jennifer A Getz, et al.
Page
of 93