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Chemical Research in Toxicology|September 29, 2012
Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: humans are more like mice than ratsImir G Metushi, Tetsuya Nakagawa, Jack Uetrecht
Molecular and Cellular Biochemistry|April 29, 2014
D-penicillamine-induced granulomatous hepatitis in brown Norway ratsImir G Metushi, Xu Zhu, Jack Uetrecht
International Journal of Molecular Sciences|April 3, 2021
Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical ChallengesAlison Jee, Samantha Christine Sernoskie, Jack Uetrecht
Drug Metabolism and Disposition: the Biological Fate of Chemicals|June 10, 2009
Bioactivation of minocycline to reactive intermediates by myeloperoxidase, horseradish peroxidase, and hepatic microsomes: implications for minocycline-induced lupus and hepatitisBaskar Mannargudi, David McNally, William Reynolds, et al.
Hepatology (Baltimore, Md.)|October 7, 2014
Treatment of PD-1(-/-) mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patientsImir G Metushi, M Anthony Hayes, Jack Uetrecht
The Journal of Toxicological Sciences|November 2, 2020
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reactionRyuji Kato, Yoshio Ijiri, Tetsuya Hayashi, et al.
Chemical Research in Toxicology|May 3, 2014
IgG3 is the dominant subtype of anti-isoniazid antibodies in patients with isoniazid-induced liver failureImir G Metushi, William M Lee, Jack Uetrecht
Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 21, 2019
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity ReactionsRyuji Kato, Yoshio Ijiri, Tetsuya Hayashi, et al.
Toxicological Sciences : an Official Journal of the Society of Toxicology|May 20, 2024
The use of PD-1 functional knockout rats to study idiosyncratic adverse reactions to nevirapineTiffany Cho, Anthony Hayes, Jeffrey T Henderson, et al.
Chemical Research in Toxicology|August 30, 2008
Demonstration of the metabolic pathway responsible for nevirapine-induced skin rashJie Chen, Baskar M Mannargudi, Ling Xu, et al.
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