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Bioorganic & Medicinal Chemistry Letters|June 24, 2016
Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTKRadoslaw Laufer, Sze-Wan Li, Yong Liu, et al.Journal of Medicinal Chemistry|July 9, 2013
The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agentsRadoslaw Laufer, Bryan Forrest, Sze-Wan Li, et al.Journal of Medicinal Chemistry|February 28, 2015
The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agentPeter B Sampson, Yong Liu, Bryan Forrest, et al.Journal of Medicinal Chemistry|May 29, 2014
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agentsPeter B Sampson, Yong Liu, Narendra Kumar Patel, et al.ACS Medicinal Chemistry Letters|July 21, 2016
Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer AgentYong Liu, Radoslaw Laufer, Narendra Kumar Patel, et al.Cancer Cell|January 27, 2015
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progressionIsaac S Harris, Aislinn E Treloar, Satoshi Inoue, et al.Bioorganic & Medicinal Chemistry|July 22, 2014
Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamidesRadoslaw Laufer, Grace Ng, Yong Liu, et al.Journal of Medicinal Chemistry|March 13, 2015
The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer AgentsYong Liu, Yunhui Lang, Narendra Kumar Patel, et al.Pageof 2