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Journal of Molecular and Cellular Cardiology|February 24, 2024
ATF6 protects against protein misfolding during cardiac hypertrophyChristoph Hofmann, Marjan Aghajani, Cecily D Alcock, et al.Molecular Therapy : the Journal of the American Society of Gene Therapy|January 12, 2025
Artificial enforcement of the unfolded protein response reduces disease features in multiple preclinical models of ALS/FTDVicente Valenzuela, Daniela Becerra, José I Astorga, et al.Journal of the American Chemical Society|May 19, 2016
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr ResidueWentao Chen, Jiajia Dong, Lars Plate, et al.Science Translational Medicine|September 15, 2017
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patientsJoseph D Schonhoft, Cecilia Monteiro, Lars Plate, et al.Biorxiv : the Preprint Server for Biology|August 2, 2024
Ribosomal Frameshifting Selectively Modulates the Assembly, Function, and Pharmacological Rescue of a Misfolded CFTR VariantPatrick Carmody, Francis J Roushar, Austin Tedman, et al.Elife|July 21, 2016
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregationLars Plate, Christina B Cooley, John J Chen, et al.Biorxiv : the Preprint Server for Biology|June 12, 2026
Profiling the CFTR Variant Selectivity and Off-Target Interactions of VX-121Ashish Rajesh Jhangiani, John A Olson, Austin Tedman, et al.Proceedings of the National Academy of Sciences of the United States of America|October 10, 2024
Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variantPatrick J Carmody, Francis J Roushar, Austin Tedman, et al.Molecular Therapy : the Journal of the American Society of Gene Therapy|February 5, 2021
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegenerationRené L Vidal, Denisse Sepulveda, Paulina Troncoso-Escudero, et al.Hepatology (Baltimore, Md.)|April 9, 2025
Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1Younis Hazari, Lama Habbouche, Valeria A Garcia Lopez, et al.Pageof 10