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Molecular Metabolism|October 1, 2016
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathwaySarbani Ghoshal, Qingzhang Zhu, Alice Asteian, et al.
ACS Medicinal Chemistry Letters|December 20, 2023
Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) InhibitorsTyler Heitmann, Gangling Liao, Pablo de León, et al.
ACS Medicinal Chemistry Letters|April 22, 2022
Discovery and Evaluation of Novel Angular Fused Pyridoquinazolinonecarboxamides as RNA Polymerase I InhibitorsTony E Dorado, Pablo de León, Asma Begum, et al.
Antimicrobial Agents and Chemotherapy|March 27, 2026
RNA Polymerase 1 inhibitors against African trypanosomes <i>in vitro</i> and in miceAlexander V Cumming, Nathaniel P Nenortas, Elizabeth Nenortas, et al.
Cellular and Molecular Gastroenterology and Hepatology|January 7, 2026
Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain SyndromesMichael S Poslusney, Qian Li, Ingrid P Buchler, et al.
Bioorganic & Medicinal Chemistry Letters|April 15, 2004
Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') groupPhilippe G Nantermet, James C Barrow, Stacey R Lindsley, et al.
Journal of Medicinal Chemistry|September 18, 2015
Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel SynthesisWilliam D Shipe, Steven S Sharik, James C Barrow, et al.
Molecular Cell|March 25, 2014
Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2Feng Rao, Jiyoung Cha, Jing Xu, et al.
Journal of Medicinal Chemistry|August 3, 2024
Identification and Characterization of a Blood-Brain Barrier Penetrant Inositol Hexakisphosphate Kinase (IP6K) InhibitorTyler Heitmann, Gangling Liao, Glen Ernst, et al.
The Journal of Pharmacology and Experimental Therapeutics|August 5, 2010
In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in miceRichard L Kraus, Yuxing Li, Yun Gregan, et al.
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