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Journal of Medicinal Chemistry|April 7, 2020
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of CancerJay B Fell, John P Fischer, Brian R Baer, et al.Cancer Discovery|October 30, 2019
The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and PatientsJill Hallin, Lars D Engstrom, Lauren Hargis, et al.Science (New York, N.Y.)|June 6, 2024
Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancersJeffrey A Klomp, Jennifer E Klomp, Clint A Stalnecker, et al.The New England Journal of Medicine|June 23, 2021
Acquired Resistance to KRASG12C Inhibition in CancerMark M Awad, Shengwu Liu, Igor I Rybkin, et al.Cancer Discovery|July 8, 2024
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic CancerJulien Dilly, Megan T Hoffman, Laleh Abbassi, et al.Pageof 13