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Journal of the American Chemical Society|April 3, 2003
Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategyBruce G Szczepankiewicz, Gang Liu, Philip J Hajduk, et al.Journal of Medicinal Chemistry|March 21, 2007
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitorsZhonghua Pei, Xiaofeng Li, Thomas W von Geldern, et al.Bioorganic & Medicinal Chemistry Letters|October 16, 2004
Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitorsHongyu Zhao, Gang Liu, Zhili Xin, et al.Journal of Cardiovascular Pharmacology|April 18, 2007
Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppressionYung-Wu Chen, Morey L Smith, Michael Sheets, et al.Journal of Medicinal Chemistry|July 25, 2003
Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligandsGang Liu, Zhili Xin, Heng Liang, et al.The Journal of Biological Chemistry|June 7, 2007
Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese miceRuojing Yang, Denise M Wilcox, Deanna L Haasch, et al.Journal of Medicinal Chemistry|May 16, 2003
Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1BGang Liu, Bruce G Szczepankiewicz, Zhonghua Pei, et al.Biochemistry|June 14, 2006
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitorsKenton L Longenecker, Kent D Stewart, David J Madar, et al.Journal of Medicinal Chemistry|July 21, 2006
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitorsHongyu Zhao, Michael D Serby, Zhili Xin, et al.Proceedings of the National Academy of Sciences of the United States of America|August 10, 2002
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic miceBradley A Zinker, Cristina M Rondinone, James M Trevillyan, et al.Pageof 4