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Pharmacology & Therapeutics|February 19, 2018
ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathwayAndrew M Kidger, James Sipthorp, Simon J CookOrganic & Biomolecular Chemistry|November 22, 2017
Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivativesBenjamin N Atkinson, Hannah L Woodward, James Sipthorp, et al.Chembiochem : a European Journal of Chemical Biology|April 8, 2017
A New Methodology for Incorporating Chiral Linkers into Stapled PeptidesJuan C Serrano, James Sipthorp, Wenshu Xu, et al.Iscience|May 26, 2021
CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cellsSougata Roy, James Sipthorp, Bidesh Mahata, et al.Bioconjugate Chemistry|April 29, 2017
Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent ProbeJames Sipthorp, Honorine Lebraud, Rebecca Gilley, et al.Cell Reports|May 11, 2024
Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasisGoran Tomić, Clare Sheridan, Alice Y Refermat, et al.Medchemcomm|September 20, 2019
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screenBenjamin N Atkinson, David Steadman, Yuguang Zhao, et al.Bioorganic & Medicinal Chemistry Letters|December 22, 2019
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitorsBenjamin N Atkinson, David Steadman, William Mahy, et al.Journal of Medicinal Chemistry|October 30, 2020
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening HitWilliam Mahy, Nicky J Willis, Yuguang Zhao, et al.Nature Biotechnology|January 8, 2024
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylationCory A Ocasio, Marc P Baggelaar, James Sipthorp, et al.Pageof 2