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Clinical and Translational Science|April 29, 2023
First-in-human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS-penetrant soluble guanylyl cyclase stimulatorSebastiaan J W van Kraaij, Pim Gal, Laura G J M Borghans, et al.Clinical Pharmacology and Therapeutics|June 28, 2022
Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover StudyTitia Q Ruijs, Ingrid W Koopmans, Marieke L de Kam, et al.Clinical and Translational Science|May 13, 2023
A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controlsMaurits F J M Vissers, Matthew D Troyer, Eva Thijssen, et al.Clinical and Translational Science|July 9, 2024
The interactive walkway provides fit-for-purpose fall-risk biomarkers in the elderly: Comparison of zolpidem and suvorexantIngrid Koopmans, Daphne Geerse, Lara de Ridder, et al.Journal of Clinical Movement Disorders|April 14, 2020
Quantification of tremor using consumer product accelerometry is feasible in patients with essential tremor and Parkinson's disease: a comparative studyEmilie M J van Brummelen, Dimitrios Ziagkos, Wadim M I de Boon, et al.JMIR Formative Research|March 15, 2023
Smartphone and Wearable Sensors for the Estimation of Facioscapulohumeral Muscular Dystrophy Disease Severity: Cross-sectional StudyAhnjili Zhuparris, Ghobad Maleki, Ingrid Koopmans, et al.Movement Disorders : Official Journal of the Movement Disorder Society|April 15, 2022
A Randomized First-in-Human Study With UB-312, a UBITh® α-Synuclein Peptide VaccineHui Jing Yu, Eva Thijssen, Emilie van Brummelen, et al.British Journal of Clinical Pharmacology|July 25, 2023
Randomized placebo-controlled crossover study to assess tolerability and pharmacodynamics of zagociguat, a soluble guanylyl cyclase stimulator, in healthy elderlySebastiaan J W van Kraaij, Laura Borghans, Erica S Klaassen, et al.Clinical Pharmacology and Therapeutics|September 1, 2020
Tolerance to Opioid-Induced Respiratory Depression in Chronic High-Dose Opioid Users: A Model-Based Comparison With Opioid-Naïve IndividualsMarijke Hyke Algera, Erik Olofsen, Laurence Moss, et al.British Journal of Anaesthesia|March 28, 2019
Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABAA partial agonist, in humansGuido van Amerongen, Pieter S Siebenga, Rachel Gurrell, et al.Pageof 12