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Bioorganic & Medicinal Chemistry Letters|May 31, 2011
Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stabilityQingsong Liu, Jinhua Wang, Seong A Kang, et al.Cancer Cell|February 3, 2009
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in miceDavid A Guertin, Deanna M Stevens, Maki Saitoh, et al.The Journal of Biological Chemistry|January 20, 2009
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1Carson C Thoreen, Seong A Kang, Jae Won Chang, et al.Aging|August 10, 2013
Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or enduranceLan Ye, Anne L Widlund, Carrie A Sims, et al.Cell|March 15, 2016
The CASTOR Proteins Are Arginine Sensors for the mTORC1 PathwayLynne Chantranupong, Sonia M Scaria, Robert A Saxton, et al.Nature|July 13, 2022
Structure of the nutrient-sensing hub GATOR2Max L Valenstein, Kacper B Rogala, Pranav V Lalgudi, et al.Cell Reports|September 30, 2014
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1Lynne Chantranupong, Rachel L Wolfson, Jose M Orozco, et al.Science (New York, N.Y.)|April 28, 2018
NUFIP1 is a ribosome receptor for starvation-induced ribophagyGregory A Wyant, Monther Abu-Remaileh, Evgeni M Frenkel, et al.Journal of Medicinal Chemistry|September 24, 2010
Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancerQingsong Liu, Jae Won Chang, Jinhua Wang, et al.Nature|March 29, 2018
Architecture of the human GATOR1 and GATOR1-Rag GTPases complexesKuang Shen, Rick K Huang, Edward J Brignole, et al.Pageof 25