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Journal of Medicinal Chemistry|December 19, 2018
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of MalariaGodfrey Mayoka, Mathew Njoroge, John Okombo, et al.Antimicrobial Agents and Chemotherapy|July 25, 2025
Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasitesEmma Y Mao, William Nguyen, Gouranga P Jana, et al.ACS Infectious Diseases|December 12, 2018
Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of ActionMalkeet Kumar, John Okombo, Dickson Mambwe, et al.Journal of Medicinal Chemistry|January 18, 2017
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse ModelKawaljit Singh, John Okombo, Christel Brunschwig, et al.Frontiers in Pharmacology|May 23, 2022
Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and CancerYabalu Z Abacha, Arnold Donkor Forkuo, Stephen Y Gbedema, et al.Journal of Medicinal Chemistry|August 14, 2025
Novel Inhibitors of Plasmodium Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and In Vivo Efficacy in a Humanized Mouse Malaria Infection ModelGodwin A Dziwornu, Mmakwena M Mmonwa, Dina Coertzen, et al.ACS Infectious Diseases|August 14, 2024
The Tuberculosis Drug Candidate SQ109 and Its Analogs Have Multistage Activity against Plasmodium falciparumSavannah J Watson, Mariëtte E van der Watt, Anjo Theron, et al.Journal of Medicinal Chemistry|October 27, 2015
A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial ImidazopyridazinesClaire Le Manach, Tanya Paquet, Christel Brunschwig, et al.Journal of Medicinal Chemistry|October 26, 2020
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse ModelAndré Horatscheck, Ana Andrijevic, Aloysius T Nchinda, et al.The Journal of Antimicrobial Chemotherapy|February 9, 2018
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarialsMariëtte E van der Watt, Janette Reader, Alisje Churchyard, et al.Pageof 6