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Journal of Medicinal Chemistry|October 18, 2016
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life CycleClaire Le Manach, Aloysius T Nchinda, Tanya Paquet, et al.Science Translational Medicine|October 19, 2022
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stagesLauren B Arendse, James M Murithi, Tarrick Qahash, et al.Nature Communications|January 12, 2021
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response BoxJanette Reader, Mariëtte E van der Watt, Dale Taylor, et al.Biorxiv : the Preprint Server for Biology|August 12, 2025
The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin FormationKathryn J Wicht, John G Woodland, Larnelle F Garnie, et al.Angewandte Chemie (International Ed. in English)|May 3, 2025
The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against MalariaJohn G Woodland, Dina Coertzen, Kathryn J Wicht, et al.ACS Chemical Biology|June 13, 2026
The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin FormationKathryn J Wicht, John G Woodland, Larnelle F Garnie, et al.Journal of Medicinal Chemistry|June 25, 2024
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo EfficacyGodwin Akpeko Dziwornu, Donald Seanego, Stephen Fienberg, et al.Journal of Medicinal Chemistry|February 12, 2021
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization EffortsClaire Le Manach, Jean Dam, John G Woodland, et al.Antimicrobial Agents and Chemotherapy|June 27, 2018
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of MalariaChristel Brunschwig, Nina Lawrence, Dale Taylor, et al.Science Advances|December 6, 2024
Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmissionPaula-Josefina Gomez-Gonzalez, Antima Gupta, Laura G Drought, et al.Pageof 6