Showing results (31-40 of 54) with videos related to
Sort By:
Pageof 6
Journal of Medicinal Chemistry|October 23, 2018
Discovery of Tarantula Venom-Derived Na<sub>V</sub>1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced PruritisBin Wu, Justin K Murray, Kristin L Andrews, et al.Journal of Medicinal Chemistry|June 17, 2008
Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)Longbin Liu, Aaron Siegmund, Ning Xi, et al.Journal of Medicinal Chemistry|April 28, 2006
Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonistsDavid E Uehling, Barry G Shearer, Kelly H Donaldson, et al.The New England Journal of Medicine|November 24, 2021
Belzutifan, a Potent HIF2α Inhibitor, in the Pacak-Zhuang SyndromeJunne Kamihara, Kayla V Hamilton, Jessica A Pollard, et al.Cellular and Molecular Gastroenterology and Hepatology|May 2, 2024
WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine ProductionAmy E O'Connell, Sathuwarman Raveenthiraraj, Luiz Fernando Silva Oliveira, et al.Journal of Medicinal Chemistry|February 21, 2015
Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitorsEmily A Peterson, Yohannes Teffera, Brian K Albrecht, et al.Proceedings of the National Academy of Sciences of the United States of America|October 27, 2005
Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580James G Conway, Brad McDonald, Janet Parham, et al.Journal of Medicinal Chemistry|January 27, 2016
Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor ActivityAlessandro A Boezio, Katrina W Copeland, Karen Rex, et al.ACS Chemical Biology|August 12, 2017
Engineering Antibody Reactivity for Efficient Derivatization to Generate Na<sub>V</sub>1.7 Inhibitory GpTx-1 Peptide-Antibody ConjugatesKaustav Biswas, Thomas E Nixey, Justin K Murray, et al.Bioorganic & Medicinal Chemistry Letters|October 13, 2009
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitorsAlessandro A Boezio, Loren Berry, Brian K Albrecht, et al.Pageof 6