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Bioorganic & Medicinal Chemistry Letters|September 6, 2016
The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonistsJason C Rech, Anindya Bhattacharya, Bryan J Branstetter, et al.ACS Medicinal Chemistry Letters|November 20, 2024
Studies of Structure-Activity Relationship of 2-(Pyrrolidin-1ylmethyl)-1<i>H</i>-pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells ActivationXinrui Yuan, Jason C Rech, Andhavaram Ramaraju, et al.Journal of Medicinal Chemistry|September 10, 2024
Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival?Duxin Sun, Christian Macedonia, Zhigang Chen, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 AntagonistsMichael A Letavic, Brian Lord, Francois Bischoff, et al.Bioorganic & Medicinal Chemistry Letters|October 12, 2010
1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved propertiesAlec D Lebsack, Jason C Rech, Bryan J Branstetter, et al.European Journal of Pharmacology|May 18, 2011
Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonistMichael P Maher, Anindya Bhattacharya, Hong Ao, et al.Science Translational Medicine|December 3, 2020
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiomeOren Rom, Yuhao Liu, Zhipeng Liu, et al.Pageof 3