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Jason G Kettle

Showing results (31-40 of 51) with videos related to

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Journal of Medicinal Chemistry|February 17, 2016
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell SurvivalJason G Kettle, Husam Alwan, Michal Bista, et al.
Bioorganic & Medicinal Chemistry Letters|September 18, 2007
Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinasePeter Ballard, Bernard C Barlaam, Robert H Bradbury, et al.
Bioorganic & Medicinal Chemistry Letters|December 7, 2007
A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinaseBernard Barlaam, Peter Ballard, Robert H Bradbury, et al.
Journal of Medicinal Chemistry|February 20, 2015
Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activationJon J G Winter, Malcolm Anderson, Kevin Blades, et al.
Journal of Medicinal Chemistry|February 12, 2013
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinasesMatt Addie, Peter Ballard, David Buttar, et al.
Molecular Cancer Therapeutics|August 5, 2022
AZD4625 is a Potent and Selective Inhibitor of KRASG12CAtanu Chakraborty, Lyndsey Hanson, David Robinson, et al.
ACS Medicinal Chemistry Letters|October 15, 2025
Focused Structure-Based Virtual Screening Identifies Novel Inhibitors of SOS1Silvia Bonomo, Floriane Gibault, Sharan K Bagal, et al.
Journal of Medicinal Chemistry|June 16, 2026
Discovery of CNS Penetrant SOS1 Inhibitors for the Treatment of KRAS-Dependent CancersSharan K Bagal, Coura R N Diène, Sandra Stefanovic-Barrett, et al.
Science Translational Medicine|May 1, 2020
Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumorsErica Banks, Michael Grondine, Deepa Bhavsar, et al.
Journal of Medicinal Chemistry|June 25, 2024
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, et al.
Pageof 6

Showing results (31-40 of 51) with videos related to

Sort By:
Pageof 6
Journal of Medicinal Chemistry|February 17, 2016
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell SurvivalJason G Kettle, Husam Alwan, Michal Bista, et al.
Bioorganic & Medicinal Chemistry Letters|September 18, 2007
Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinasePeter Ballard, Bernard C Barlaam, Robert H Bradbury, et al.
Bioorganic & Medicinal Chemistry Letters|December 7, 2007
A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinaseBernard Barlaam, Peter Ballard, Robert H Bradbury, et al.
Journal of Medicinal Chemistry|February 20, 2015
Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activationJon J G Winter, Malcolm Anderson, Kevin Blades, et al.
Journal of Medicinal Chemistry|February 12, 2013
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinasesMatt Addie, Peter Ballard, David Buttar, et al.
Molecular Cancer Therapeutics|August 5, 2022
AZD4625 is a Potent and Selective Inhibitor of KRASG12CAtanu Chakraborty, Lyndsey Hanson, David Robinson, et al.
ACS Medicinal Chemistry Letters|October 15, 2025
Focused Structure-Based Virtual Screening Identifies Novel Inhibitors of SOS1Silvia Bonomo, Floriane Gibault, Sharan K Bagal, et al.
Journal of Medicinal Chemistry|June 16, 2026
Discovery of CNS Penetrant SOS1 Inhibitors for the Treatment of KRAS-Dependent CancersSharan K Bagal, Coura R N Diène, Sandra Stefanovic-Barrett, et al.
Science Translational Medicine|May 1, 2020
Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumorsErica Banks, Michael Grondine, Deepa Bhavsar, et al.
Journal of Medicinal Chemistry|June 25, 2024
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, et al.
Pageof 6