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Bioorganic & Medicinal Chemistry Letters
|
March 17, 2020
Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models
Youheng Shu, Tracy L Diamond, James C Hershey, et al.
Journal of Medicinal Chemistry
|
September 18, 2015
Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis
William D Shipe, Steven S Sharik, James C Barrow, et al.
Sleep
|
March 5, 2016
Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys
Pamela L Tannenbaum, Spencer J Tye, Joanne Stevens, et al.
ACS Medicinal Chemistry Letters
|
June 19, 2024
2-Aminopyridines as Potent and Selective Na<sub>v</sub>1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
Michael J Breslin, Jeffrey W Schubert, Deping Wang, et al.
ACS Medicinal Chemistry Letters
|
August 22, 2018
Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor
Shawn J Stachel, Richard Berger, Ashley B Nomland, et al.
BMC Neuroscience
|
September 23, 2014
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators
Anthony L Gotter, Susan L Garson, Joanne Stevens, et al.
Frontiers in Behavioral Neuroscience
|
June 7, 2014
Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs
Pamela L Tannenbaum, Joanne Stevens, Jacquelyn Binns, et al.
Neuropharmacology
|
November 30, 2010
T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats
Jason M Uslaner, Sean M Smith, Sarah L Huszar, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
June 21, 2014
Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders
Mikhail Kalinichev, Emmanuel Le Poul, Christelle Boléa, et al.
ACS Medicinal Chemistry Letters
|
June 6, 2014
Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor
Robert M Garbaccio, Edward J Brnardic, Mark E Fraley, et al.
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Search research articles
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Showing results (41-50 of 71) with videos related to
Sort By:
Page
of 8
Bioorganic & Medicinal Chemistry Letters
|
March 17, 2020
Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models
Youheng Shu, Tracy L Diamond, James C Hershey, et al.
Journal of Medicinal Chemistry
|
September 18, 2015
Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis
William D Shipe, Steven S Sharik, James C Barrow, et al.
Sleep
|
March 5, 2016
Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys
Pamela L Tannenbaum, Spencer J Tye, Joanne Stevens, et al.
ACS Medicinal Chemistry Letters
|
June 19, 2024
2-Aminopyridines as Potent and Selective Na<sub>v</sub>1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
Michael J Breslin, Jeffrey W Schubert, Deping Wang, et al.
ACS Medicinal Chemistry Letters
|
August 22, 2018
Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor
Shawn J Stachel, Richard Berger, Ashley B Nomland, et al.
BMC Neuroscience
|
September 23, 2014
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators
Anthony L Gotter, Susan L Garson, Joanne Stevens, et al.
Frontiers in Behavioral Neuroscience
|
June 7, 2014
Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs
Pamela L Tannenbaum, Joanne Stevens, Jacquelyn Binns, et al.
Neuropharmacology
|
November 30, 2010
T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats
Jason M Uslaner, Sean M Smith, Sarah L Huszar, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
June 21, 2014
Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders
Mikhail Kalinichev, Emmanuel Le Poul, Christelle Boléa, et al.
ACS Medicinal Chemistry Letters
|
June 6, 2014
Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor
Robert M Garbaccio, Edward J Brnardic, Mark E Fraley, et al.
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