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Molecules (Basel, Switzerland)
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January 5, 2021
SYN-View: A Phylogeny-Based Synteny Exploration Tool for the Identification of Gene Clusters Linked to Antibiotic Resistance
Jason Stahlecker, Erik Mingyar, Nadine Ziemert, et al.
ACS Pharmacology & Translational Science
|
December 19, 2024
Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution
Theresa Klett, Jason Stahlecker, Simon Jaag, et al.
Drug Design, Development and Therapy
|
May 25, 2026
Characterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue
Martin Schwer, Sven R Aldea, Marc U Engelhardt, et al.
Journal of Medicinal Chemistry
|
October 26, 2022
Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes
Marcel Dammann, Jason Stahlecker, Markus O Zimmermann, et al.
Drug Design, Development and Therapy
|
July 2, 2025
S<sub>N</sub>Ar Reactive Pyrazine Derivatives as p53-Y220C Cleft Binders with Diverse Binding Modes
Theresa Klett, Jason Stahlecker, Martin Schwer, et al.
Protein Science : a Publication of the Protein Society
|
May 16, 2026
Covalent drug rescue of multiple p53 mutants by stabilizing vinyl sulfone fragments hints to a specific refolding mechanism for R282W
Jason Stahlecker, Theresa Klett, Robert Spiegel, et al.
Journal of Chemical Theory and Computation
|
September 18, 2024
Halogen Bonding on Water─A Drop in the Ocean?
Marc U Engelhardt, Markus O Zimmermann, Marcel Dammann, et al.
Journal of Medicinal Chemistry
|
July 24, 2023
Principles and Applications of CF<sub>2</sub>X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery
Sebastian Vaas, Markus O Zimmermann, Dieter Schollmeyer, et al.
Archiv Der Pharmazie
|
August 11, 2025
Design, Synthesis, and Molecular Evaluation of S<sub>N</sub>Ar-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode
Larissa N Ernst, Jason Stahlecker, Finn Mier, et al.
RSC Medicinal Chemistry
|
December 23, 2022
Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C
Jason Stahlecker, Theresa Klett, Martin Schwer, et al.
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Search research articles
Search
Showing results (1-10 of 10) with videos related to
Sort By:
Page
of 1
Molecules (Basel, Switzerland)
|
January 5, 2021
SYN-View: A Phylogeny-Based Synteny Exploration Tool for the Identification of Gene Clusters Linked to Antibiotic Resistance
Jason Stahlecker, Erik Mingyar, Nadine Ziemert, et al.
ACS Pharmacology & Translational Science
|
December 19, 2024
Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution
Theresa Klett, Jason Stahlecker, Simon Jaag, et al.
Drug Design, Development and Therapy
|
May 25, 2026
Characterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue
Martin Schwer, Sven R Aldea, Marc U Engelhardt, et al.
Journal of Medicinal Chemistry
|
October 26, 2022
Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes
Marcel Dammann, Jason Stahlecker, Markus O Zimmermann, et al.
Drug Design, Development and Therapy
|
July 2, 2025
S<sub>N</sub>Ar Reactive Pyrazine Derivatives as p53-Y220C Cleft Binders with Diverse Binding Modes
Theresa Klett, Jason Stahlecker, Martin Schwer, et al.
Protein Science : a Publication of the Protein Society
|
May 16, 2026
Covalent drug rescue of multiple p53 mutants by stabilizing vinyl sulfone fragments hints to a specific refolding mechanism for R282W
Jason Stahlecker, Theresa Klett, Robert Spiegel, et al.
Journal of Chemical Theory and Computation
|
September 18, 2024
Halogen Bonding on Water─A Drop in the Ocean?
Marc U Engelhardt, Markus O Zimmermann, Marcel Dammann, et al.
Journal of Medicinal Chemistry
|
July 24, 2023
Principles and Applications of CF<sub>2</sub>X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery
Sebastian Vaas, Markus O Zimmermann, Dieter Schollmeyer, et al.
Archiv Der Pharmazie
|
August 11, 2025
Design, Synthesis, and Molecular Evaluation of S<sub>N</sub>Ar-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode
Larissa N Ernst, Jason Stahlecker, Finn Mier, et al.
RSC Medicinal Chemistry
|
December 23, 2022
Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C
Jason Stahlecker, Theresa Klett, Martin Schwer, et al.
Page
of 1