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Journal of Medicinal Chemistry|November 8, 2013
Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymeraseFrancisco X Talamas, Sarah C Abbot, Shalini Anand, et al.Bioorganic & Medicinal Chemistry Letters|August 28, 2009
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxidesJavier de Vicente, Robert T Hendricks, David B Smith, et al.Journal of Medicinal Chemistry|December 5, 2022
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral SclerosisRobert A Craig, Brian M Fox, Cheng Hu, et al.Molecular Neurodegeneration|August 7, 2025
LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosomeMichael T Maloney, Xiang Wang, Rajarshi Ghosh, et al.Bioorganic & Medicinal Chemistry Letters|August 25, 2009
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acidsJavier de Vicente, Robert T Hendricks, David B Smith, et al.Bioorganic & Medicinal Chemistry Letters|May 22, 2009
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinedionesJavier de Vicente, Robert T Hendricks, David B Smith, et al.Science Translational Medicine|June 8, 2022
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's diseaseDanna Jennings, Sarah Huntwork-Rodriguez, Anastasia G Henry, et al.Journal of Medicinal Chemistry|July 8, 2020
Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative BacteriaColin K Skepper, Duncan Armstrong, Carl J Balibar, et al.Pageof 3