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Mabs|August 19, 2015
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1βJean-Michel Rondeau, Paul Ramage, Mauro Zurini, et al.Scientific Reports|August 23, 2017
The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition propertiesArnaud Goepfert, Sylvie Lehmann, Emmanuelle Wirth, et al.Bioorganic & Medicinal Chemistry Letters|January 5, 2002
Structure-based design and protein X-ray analysis of a protein kinase inhibitorPascal Furet, Thomas Meyer, André Strauss, et al.Immunity|March 19, 2020
Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent SignalingArnaud Goepfert, Sylvie Lehmann, Jutta Blank, et al.Bioorganic & Medicinal Chemistry Letters|February 23, 2010
Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitorsStephen Hanessian, Zhihui Shao, Claudia Betschart, et al.Journal of Medicinal Chemistry|July 21, 2006
Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE)Stephen Hanessian, Gaoqiang Yang, Jean-Michel Rondeau, et al.Bioorganic & Medicinal Chemistry Letters|February 7, 2009
Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitorsRainer Machauer, Siem Veenstra, Jean-Michel Rondeau, et al.Bioorganic & Medicinal Chemistry Letters|March 11, 2011
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitorsHeinrich Rueeger, Jean-Michel Rondeau, Clive McCarthy, et al.Journal of the American Society for Mass Spectrometry|January 20, 2025
Revealing Unpredicted Aspartic Acid Isomerization Hotspots by Probing Diagnostic Fragmentation Propensities in Top-Down and Middle-Down Mass SpectrometryBlandine Denefeld, Joanna Hajduk, Jure Cerar, et al.Mabs|October 19, 2025
IL-17A complexes with therapeutic antibodies exhibit distinct size distributions, potentially contributing to clinically observed immunogenicityDennis Ungan, Céline Be, Paulina Baczyk, et al.Pageof 4