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Clinical and Translational Science|November 27, 2023
Safety, pharmacokinetics, and target engagement of a brain penetrant RIPK1 inhibitor, SAR443820 (DNL788), in healthy adult participantsAgnes Hincelin-Mery, Xavier Nicolas, Cathy Cantalloube, et al.Annals of Clinical and Translational Neurology|June 10, 2020
Longitudinal biomarkers in amyotrophic lateral sclerosisFen Huang, Yuda Zhu, Jennifer Hsiao-Nakamoto, et al.Immunity|March 25, 2025
Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesisMatija Zelic, Anna Blazier, Fabrizio Pontarelli, et al.Biorxiv : the Preprint Server for Biology|February 26, 2024
Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal DementiaJennifer Hsiao-Nakamoto, Chi-Lu Chiu, Lawren VandeVrede, et al.Clinical and Translational Science|June 1, 2022
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patientsMaurits F J M Vissers, Jules A A C Heuberger, Geert Jan Groeneveld, et al.Cell|November 12, 2024
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomesJing L Guo, Dylan Braun, Gabriel A Fitzgerald, et al.Cell|August 27, 2021
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologicTodd Logan, Matthew J Simon, Anil Rana, et al.Pageof 1