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European Journal of Pharmacology|October 24, 2009
Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat modelStephan Grant, Phong Tran, Qin Zhang, et al.American Journal of Physiology. Renal Physiology|September 26, 2024
Acute kidney injury results in long-term alterations of kidney lymphatics in miceGelare Ghajar-Rahimi, Daria Barwinska, Grace E Whipple, et al.The Journal of Organic Chemistry|July 18, 2025
Development of a Scalable Synthesis of a HPK1 Inhibitor Featuring a Direct α-Arylation of Boc-Protected N,N-Dimethylamine by Palladium-Mediated Negishi Cross-CouplingDahui Zhou, Matthew Del Bel, Thomas Knauber, et al.Journal of Medicinal Chemistry|December 5, 2025
Discovery of Atirmociclib (PF-07220060): A Potent and Selective CDK4 InhibitorGary M Gallego, Cynthia Palmer, Suvi Orr, et al.Research Square|January 30, 2023
Spatiotemporal immune atlas of the first clinical-grade, gene-edited pig-to-human kidney xenotransplantMatthew D Cheung, Rebecca Asiimwe, Elise N Erman, et al.Nature Communications|April 11, 2024
Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplantMatthew D Cheung, Rebecca Asiimwe, Elise N Erman, et al.Journal of Medicinal Chemistry|November 5, 2024
Discovery of Highly Selective Inhibitors of Microtubule-Associated Serine/Threonine Kinase-like (MASTL)Rebecca A Gallego, Stephanie Scales, Chad Toledo, et al.Journal of Medicinal Chemistry|December 28, 2020
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)Hengmiao Cheng, Suvi T M Orr, Simon Bailey, et al.Journal of Medicinal Chemistry|March 20, 2023
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1Rebecca A Gallego, Louise Bernier, Hui Chen, et al.Journal of Medicinal Chemistry|March 14, 2017
Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFRSimon Planken, Douglas C Behenna, Sajiv K Nair, et al.Pageof 3