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Bioorganic & Medicinal Chemistry Letters
|
August 25, 2015
Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists
Bin Liu, Carrie H Croy, Stephen A Hitchcock, et al.
Journal of Medicinal Chemistry
|
May 3, 2012
Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer
Essa Hu, Ji Ma, Christopher Biorn, et al.
Journal of Medicinal Chemistry
|
July 26, 2014
Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A)
Essa Hu, Ning Chen, Matthew P Bourbeau, et al.
Bioorganic & Medicinal Chemistry
|
December 3, 2014
Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility
Robert M Rzasa, Michael J Frohn, Kristin L Andrews, et al.
Journal of Medicinal Chemistry
|
August 28, 2018
Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine
Daniel B Horne, Kaustav Biswas, James Brown, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
December 16, 2014
AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer
Hang Chen, Dianna Lester-Zeiner, Jianxia Shi, et al.
Journal of Medicinal Chemistry
|
March 14, 2022
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe
Nuria A Tamayo, Matthew P Bourbeau, Jennifer R Allen, et al.
Nature Cancer
|
December 27, 2023
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers
Marc Payton, Brian Belmontes, Kelly Hanestad, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 22, 2013
Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease
Jian Jeffrey Chen, Wenyuan Qian, Kaustav Biswas, et al.
Journal of Medicinal Chemistry
|
February 11, 2025
Identification of Structurally Novel KRAS<sup>G12C</sup> Inhibitors through Covalent DNA-Encoded Library Screening
David Huang, Francesco Manoni, Zhen Sun, et al.
Page
of 4
Search research articles
Search
Showing results (21-30 of 35) with videos related to
Sort By:
Page
of 4
Bioorganic & Medicinal Chemistry Letters
|
August 25, 2015
Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists
Bin Liu, Carrie H Croy, Stephen A Hitchcock, et al.
Journal of Medicinal Chemistry
|
May 3, 2012
Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer
Essa Hu, Ji Ma, Christopher Biorn, et al.
Journal of Medicinal Chemistry
|
July 26, 2014
Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A)
Essa Hu, Ning Chen, Matthew P Bourbeau, et al.
Bioorganic & Medicinal Chemistry
|
December 3, 2014
Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility
Robert M Rzasa, Michael J Frohn, Kristin L Andrews, et al.
Journal of Medicinal Chemistry
|
August 28, 2018
Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine
Daniel B Horne, Kaustav Biswas, James Brown, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
December 16, 2014
AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer
Hang Chen, Dianna Lester-Zeiner, Jianxia Shi, et al.
Journal of Medicinal Chemistry
|
March 14, 2022
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe
Nuria A Tamayo, Matthew P Bourbeau, Jennifer R Allen, et al.
Nature Cancer
|
December 27, 2023
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers
Marc Payton, Brian Belmontes, Kelly Hanestad, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 22, 2013
Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease
Jian Jeffrey Chen, Wenyuan Qian, Kaustav Biswas, et al.
Journal of Medicinal Chemistry
|
February 11, 2025
Identification of Structurally Novel KRAS<sup>G12C</sup> Inhibitors through Covalent DNA-Encoded Library Screening
David Huang, Francesco Manoni, Zhen Sun, et al.
Page
of 4