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Jere E Meredith

Showing results (11-20 of 24) with videos related to

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Bioorganic & Medicinal Chemistry Letters|October 27, 2015
Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)Kenneth M Boy, Jason M Guernon, Yong-Jin Wu, et al.
Bioorganic & Medicinal Chemistry Letters|July 26, 2011
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)Kenneth M Boy, Jason M Guernon, Jianliang Shi, et al.
Journal of Medicinal Chemistry|October 4, 2012
Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesisSamuel W Gerritz, Weixu Zhai, Shuhao Shi, et al.
The Journal of Pharmacology and Experimental Therapeutics|May 24, 2008
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in miceJere E Meredith, Lorin A Thompson, Jeremy H Toyn, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|May 25, 2012
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027Donna M Barten, Patrizia Fanara, Cathy Andorfer, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase InhibitorKevin W Gillman, John E Starrett, Michael F Parker, et al.
Bioorganic & Medicinal Chemistry Letters|November 17, 2010
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1Lawrence R Marcin, Mendi A Higgins, F Christopher Zusi, et al.
Bioorganic & Medicinal Chemistry Letters|October 7, 2011
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitorsLorin A Thompson, Jianliang Shi, Carl P Decicco, et al.
ACS Medicinal Chemistry Letters|March 21, 2019
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481Kenneth M Boy, Jason M Guernon, Dmitry S Zuev, et al.
The Journal of Pharmacology and Experimental Therapeutics|May 19, 2016
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human SubjectsJeremy H Toyn, Kenneth M Boy, Joseph Raybon, et al.
Pageof 3

Showing results (11-20 of 24) with videos related to

Sort By:
Pageof 3
Bioorganic & Medicinal Chemistry Letters|October 27, 2015
Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)Kenneth M Boy, Jason M Guernon, Yong-Jin Wu, et al.
Bioorganic & Medicinal Chemistry Letters|July 26, 2011
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)Kenneth M Boy, Jason M Guernon, Jianliang Shi, et al.
Journal of Medicinal Chemistry|October 4, 2012
Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesisSamuel W Gerritz, Weixu Zhai, Shuhao Shi, et al.
The Journal of Pharmacology and Experimental Therapeutics|May 24, 2008
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in miceJere E Meredith, Lorin A Thompson, Jeremy H Toyn, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|May 25, 2012
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027Donna M Barten, Patrizia Fanara, Cathy Andorfer, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase InhibitorKevin W Gillman, John E Starrett, Michael F Parker, et al.
Bioorganic & Medicinal Chemistry Letters|November 17, 2010
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1Lawrence R Marcin, Mendi A Higgins, F Christopher Zusi, et al.
Bioorganic & Medicinal Chemistry Letters|October 7, 2011
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitorsLorin A Thompson, Jianliang Shi, Carl P Decicco, et al.
ACS Medicinal Chemistry Letters|March 21, 2019
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481Kenneth M Boy, Jason M Guernon, Dmitry S Zuev, et al.
The Journal of Pharmacology and Experimental Therapeutics|May 19, 2016
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human SubjectsJeremy H Toyn, Kenneth M Boy, Joseph Raybon, et al.
Pageof 3