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Journal of Medicinal Chemistry
|
August 5, 2022
GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1
Alexander M Taylor, Chris Bailey, Lisa D Belmont, et al.
Bioorganic & Medicinal Chemistry Letters
|
June 8, 2012
Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Daniel P Sutherlin, Stewart Baker, Angelina Bisconte, et al.
Journal of Medicinal Chemistry
|
May 15, 2013
Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors
Jun Liang, Anne van Abbema, Mercedesz Balazs, et al.
Journal of Medicinal Chemistry
|
February 5, 2019
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma
Xiaojing Wang, Wesley Blackaby, Vivienne Allen, et al.
ACS Medicinal Chemistry Letters
|
July 26, 2017
GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2)
Terry D Crawford, James E Audia, Steve Bellon, et al.
Journal of Medicinal Chemistry
|
May 25, 2016
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains
Terry D Crawford, Vickie Tsui, E Megan Flynn, et al.
ACS Medicinal Chemistry Letters
|
June 17, 2026
Optimization and <i>In Vivo</i> Characterization of a Series of Cbl‑b Inactive-State Inhibitors
Michael J Lambrecht, Jun Liang, Peter Man-Un Ung, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 17, 2019
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma
Sarah M Bronner, Karl A Merrick, Jeremy Murray, et al.
ACS Medicinal Chemistry Letters
|
June 19, 2024
Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding
Jun Liang, Michael J Lambrecht, Teresita L Arenzana, et al.
Journal of Medicinal Chemistry
|
September 12, 2017
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
F Anthony Romero, Jeremy Murray, Kwong Wah Lai, et al.
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of 7
Search research articles
Search
Showing results (51-60 of 65) with videos related to
Sort By:
Page
of 7
Journal of Medicinal Chemistry
|
August 5, 2022
GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1
Alexander M Taylor, Chris Bailey, Lisa D Belmont, et al.
Bioorganic & Medicinal Chemistry Letters
|
June 8, 2012
Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Daniel P Sutherlin, Stewart Baker, Angelina Bisconte, et al.
Journal of Medicinal Chemistry
|
May 15, 2013
Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors
Jun Liang, Anne van Abbema, Mercedesz Balazs, et al.
Journal of Medicinal Chemistry
|
February 5, 2019
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma
Xiaojing Wang, Wesley Blackaby, Vivienne Allen, et al.
ACS Medicinal Chemistry Letters
|
July 26, 2017
GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2)
Terry D Crawford, James E Audia, Steve Bellon, et al.
Journal of Medicinal Chemistry
|
May 25, 2016
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains
Terry D Crawford, Vickie Tsui, E Megan Flynn, et al.
ACS Medicinal Chemistry Letters
|
June 17, 2026
Optimization and <i>In Vivo</i> Characterization of a Series of Cbl‑b Inactive-State Inhibitors
Michael J Lambrecht, Jun Liang, Peter Man-Un Ung, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 17, 2019
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma
Sarah M Bronner, Karl A Merrick, Jeremy Murray, et al.
ACS Medicinal Chemistry Letters
|
June 19, 2024
Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding
Jun Liang, Michael J Lambrecht, Teresita L Arenzana, et al.
Journal of Medicinal Chemistry
|
September 12, 2017
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
F Anthony Romero, Jeremy Murray, Kwong Wah Lai, et al.
Page
of 7