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Scientific Reports
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December 8, 2019
The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis
Jianghua Tu, Soohyun Park, Wangsheng Yu, et al.
Science Signaling
|
December 2, 2020
Unlike LGR4, LGR5 potentiates Wnt-β-catenin signaling without sequestering E3 ligases
Soohyun Park, Ling Wu, Jianghua Tu, et al.
Scientific Reports
|
July 4, 2023
LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43/ZNRF3 to provide high affinity binding of R-spondin ligands
Yukimatsu Toh, Ling Wu, Soohyun Park, et al.
Biorxiv : the Preprint Server for Biology
|
September 2, 2025
RSPO2-based peptibodies conjugated with pyrrolobenzodiazepine dimer or camptothecin analogs demonstrate potent anti-tumor activity by targeting the three receptors LGR4/5/6
Yukimatsu Toh, Jianghua Tu, Ling Wu, et al.
Journal of Medicinal Chemistry
|
August 18, 2021
Drug Conjugates of Antagonistic R-Spondin 4 Mutant for Simultaneous Targeting of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors 4/5/6 for Cancer Treatment
Jie Cui, Yukimatsu Toh, Soohyun Park, et al.
Pharmaceutics
|
July 27, 2024
Antitumor Activity of a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting LGR5 in Preclinical Models of Neuroblastoma
Jianghua Tu, Yukimatsu Toh, Adela M Aldana, et al.
Journal of Medicinal Chemistry
|
April 9, 2026
RSPO2-Based Peptibodies Conjugated with Pyrrolobenzodiazepine Dimer or Camptothecin Analogs Demonstrate Potent Antitumor Activity by Targeting the Three Receptors LGR4/5/6 in Colorectal Cancer and Neuroblastoma
Yukimatsu Toh, Jianghua Tu, Ling Wu, et al.
Biorxiv : the Preprint Server for Biology
|
October 17, 2024
Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer
Yukimatsu Toh, Ling Wu, Jianghua Tu, et al.
British Journal of Cancer
|
August 18, 2025
Anti-tumor activity of camptothecin analog conjugate of an RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer
Yukimatsu Toh, Ling Wu, Jianghua Tu, et al.
Biorxiv : the Preprint Server for Biology
|
January 23, 2024
Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
Fei Yue, Amy T Ku, Payton D Stevens, et al.
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Search research articles
Search
Showing results (1-10 of 11) with videos related to
Sort By:
Page
of 2
Scientific Reports
|
December 8, 2019
The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis
Jianghua Tu, Soohyun Park, Wangsheng Yu, et al.
Science Signaling
|
December 2, 2020
Unlike LGR4, LGR5 potentiates Wnt-β-catenin signaling without sequestering E3 ligases
Soohyun Park, Ling Wu, Jianghua Tu, et al.
Scientific Reports
|
July 4, 2023
LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43/ZNRF3 to provide high affinity binding of R-spondin ligands
Yukimatsu Toh, Ling Wu, Soohyun Park, et al.
Biorxiv : the Preprint Server for Biology
|
September 2, 2025
RSPO2-based peptibodies conjugated with pyrrolobenzodiazepine dimer or camptothecin analogs demonstrate potent anti-tumor activity by targeting the three receptors LGR4/5/6
Yukimatsu Toh, Jianghua Tu, Ling Wu, et al.
Journal of Medicinal Chemistry
|
August 18, 2021
Drug Conjugates of Antagonistic R-Spondin 4 Mutant for Simultaneous Targeting of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors 4/5/6 for Cancer Treatment
Jie Cui, Yukimatsu Toh, Soohyun Park, et al.
Pharmaceutics
|
July 27, 2024
Antitumor Activity of a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting LGR5 in Preclinical Models of Neuroblastoma
Jianghua Tu, Yukimatsu Toh, Adela M Aldana, et al.
Journal of Medicinal Chemistry
|
April 9, 2026
RSPO2-Based Peptibodies Conjugated with Pyrrolobenzodiazepine Dimer or Camptothecin Analogs Demonstrate Potent Antitumor Activity by Targeting the Three Receptors LGR4/5/6 in Colorectal Cancer and Neuroblastoma
Yukimatsu Toh, Jianghua Tu, Ling Wu, et al.
Biorxiv : the Preprint Server for Biology
|
October 17, 2024
Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer
Yukimatsu Toh, Ling Wu, Jianghua Tu, et al.
British Journal of Cancer
|
August 18, 2025
Anti-tumor activity of camptothecin analog conjugate of an RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer
Yukimatsu Toh, Ling Wu, Jianghua Tu, et al.
Biorxiv : the Preprint Server for Biology
|
January 23, 2024
Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
Fei Yue, Amy T Ku, Payton D Stevens, et al.
Page
of 2