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ACS Medicinal Chemistry Letters|July 21, 2016
Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical StudiesEssa Hu, Ning Chen, Roxanne K Kunz, et al.ACS Medicinal Chemistry Letters|June 20, 2014
Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)Essa Hu, Kristin Andrews, Samer Chmait, et al.Journal of Medicinal Chemistry|October 10, 2013
Design, optimization, and biological evaluation of novel keto-benzimidazoles as potent and selective inhibitors of phosphodiesterase 10A (PDE10A)Essa Hu, Roxanne K Kunz, Ning Chen, et al.Chemistry & Biology|October 27, 2007
Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbetaMichael J Gorczynski, Jolanta Grembecka, Yunpeng Zhou, et al.Journal of Medicinal Chemistry|May 3, 2012
Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracerEssa Hu, Ji Ma, Christopher Biorn, et al.Journal of Medicinal Chemistry|July 26, 2014
Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A)Essa Hu, Ning Chen, Matthew P Bourbeau, et al.The Journal of Pharmacology and Experimental Therapeutics|December 16, 2014
AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracerHang Chen, Dianna Lester-Zeiner, Jianxia Shi, et al.Pageof 2