Showing results (11-20 of 41) with videos related to
Sort By:
Pageof 5
Biochemistry|April 28, 2007
Structure of the catalytic domain of human polo-like kinase 1Michael Kothe, Darcy Kohls, Simon Low, et al.Bioorganic & Medicinal Chemistry Letters|August 21, 2014
Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitorsLan Wang, Mark Stanley, Jason W Boggs, et al.Journal of Medicinal Chemistry|February 13, 2009
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitorHui Li, John Tatlock, Angelica Linton, et al.Bioorganic & Medicinal Chemistry Letters|December 26, 2012
Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinaseSteven T Staben, Nicole Blaquiere, Vickie Tsui, et al.ACS Medicinal Chemistry Letters|April 21, 2016
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTORTimothy P Heffron, Chudi O Ndubaku, Laurent Salphati, et al.Bioorganic & Medicinal Chemistry Letters|July 23, 2013
Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivityBrian S Safina, Zachary K Sweeney, Jun Li, et al.Journal of Medicinal Chemistry|September 6, 2012
The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase αTimothy P Heffron, Laurent Salphati, Bruno Alicke, et al.Journal of Medicinal Chemistry|October 12, 2011
Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoformTimothy P Heffron, Binqing Wei, Alan Olivero, et al.Journal of Medicinal Chemistry|March 12, 2013
Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR)Anthony A Estrada, Daniel G Shore, Elizabeth Blackwood, et al.Bioorganic & Medicinal Chemistry Letters|March 30, 2010
Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitorTimothy P Heffron, Megan Berry, Georgette Castanedo, et al.Pageof 5