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Journal of Medicinal Chemistry|December 4, 2012
Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activityMichael F T Koehler, Philippe Bergeron, Elizabeth Blackwood, et al.Journal of Medicinal Chemistry|March 29, 2014
Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimizationTerry D Crawford, Chudi O Ndubaku, Huifen Chen, et al.Journal of Medicinal Chemistry|August 11, 2012
Potent and highly selective benzimidazole inhibitors of PI3-kinase deltaJeremy M Murray, Zachary K Sweeney, Bryan K Chan, et al.ACS Medicinal Chemistry Letters|August 20, 2015
Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal AngiogenesisChudi O Ndubaku, Terry D Crawford, Huifen Chen, et al.Journal of Medicinal Chemistry|April 19, 2011
Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidineFrederick Cohen, Philippe Bergeron, Elizabeth Blackwood, et al.Molecular Cancer Therapeutics|October 15, 2011
GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathwayJeffrey J Wallin, Kyle A Edgar, Jane Guan, et al.Bioorganic & Medicinal Chemistry Letters|June 4, 2011
Structure-based design of thienobenzoxepin inhibitors of PI3-kinaseSteven T Staben, Michael Siu, Richard Goldsmith, et al.Journal of Medicinal Chemistry|January 7, 2010
Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancerDaniel P Sutherlin, Deepak Sampath, Megan Berry, et al.Nature Immunology|March 22, 2022
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunityRosa Barreira da Silva, Ricardo M Leitao, Ximo Pechuan-Jorge, et al.Bioorganic & Medicinal Chemistry Letters|September 9, 2010
Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinaseSteven T Staben, Timothy P Heffron, Daniel P Sutherlin, et al.Pageof 5