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Cell Reports. Medicine|December 30, 2025
DF6215, an α-optimized IL-2-Fc fusion, expands immune effectors and drives robust preclinical anti-tumor activityAdam P Stockmann, Sylvia Vincent, Lauren Herschelman, et al.
The Journal of Prevention of Alzheimer'S Disease|July 11, 2025
Associations of cardiovascular health assessed by life's crucial 9 with incident cardiovascular disease and dementia: A prospective cohort studyYiwen Dai, Yuling Liu, Yang Pan, et al.
Acta Psychiatrica Scandinavica|August 5, 2025
Association Between Age at Diagnosis of Coronary Heart Disease and Incident Depression and AnxietyJie Liang, Qiongwei Li, Yang Pan, et al.
Cell Biochemistry and Biophysics|June 12, 2013
Absolute quantification of E1, ubiquitin-like proteins and Nedd8-MLN4924 adduct by mass spectrometryXiaofeng Yang, James E Brownell, Qing Xu, et al.
The Journal of Biological Chemistry|March 20, 2012
Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6James M Gavin, Jesse J Chen, Hua Liao, et al.
The Journal of Biological Chemistry|June 27, 2014
Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathwayJames M Gavin, Kara Hoar, Qing Xu, et al.
The Journal of Biological Chemistry|October 5, 2011
Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analoguesJesse J Chen, Christopher A Tsu, James M Gavin, et al.
Cancer Cell|March 24, 2012
Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924Michael A Milhollen, Michael P Thomas, Usha Narayanan, et al.
Molecular Cell|February 5, 2010
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situJames E Brownell, Michael D Sintchak, James M Gavin, et al.
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