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Nature|July 22, 2014
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomideEric S Fischer, Kerstin Böhm, John R Lydeard, et al.Journal of Medicinal Chemistry|January 31, 2013
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophoreNils Ostermann, Simon Ruedisser, Claus Ehrhardt, et al.Proceedings of the National Academy of Sciences of the United States of America|May 11, 2019
Structure of lipoprotein lipase in complex with GPIHBP1Rishi Arora, Amitabh V Nimonkar, Daniel Baird, et al.Plos One|January 11, 2017
Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EEDLing Li, Hailong Zhang, Man Zhang, et al.ACS Chemical Biology|January 3, 2023
Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC InteractionJian Ding, Guo Li, Hejun Liu, et al.Journal of Medicinal Chemistry|November 18, 2022
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS<sup>G12C</sup> for the Treatment of Solid TumorsEdwige Lorthiois, Marc Gerspacher, Kim S Beyer, et al.Cancer Discovery|April 11, 2022
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12CAndreas Weiss, Edwige Lorthiois, Louise Barys, et al.Cell Chemical Biology|September 21, 2021
Identification of a PCSK9-LDLR disruptor peptide with in vivo functionMargaret E Brousseau, Kevin B Clairmont, Glen Spraggon, et al.Nature Communications|August 15, 2023
Diversity-oriented synthesis encoded by deoxyoligonucleotidesLiam Hudson, Jeremy W Mason, Matthias V Westphal, et al.Cell|April 3, 2025
Therapeutic potential of allosteric HECT E3 ligase inhibitionAlexander M K Rothman, Amir Florentin, Florence Zink, et al.Pageof 3